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Study Information
Study Attribute Value
CEBS Accession Number: 002-01833-0001-0000-8
Chemical Name: Carbon tetrachloride
CASRN: 56-23-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 398542_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/26/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 453 0.434 9.06 26.5 0.000
Test Chemical Carbon tetrachloride 
595         
 50 1046 513 0.490 10.26 26.5 13.029 
745         
 50 1039 490 0.472 9.80 26.5 8.688 
1490         
 50 1039 517 0.498 10.34 26.5 14.677 
2970         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 579 0.552 11.58 27.0 27.205
Mitomycin-C 
 0.01      
 10 210 776 3.695 77.60 27.0 751.618
Trend: 1.933        
Probability: 0.027        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/29/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 400 0.381 8.00 25.0 0.000
Test Chemical Carbon tetrachloride 
156         
 50 1039 449 0.432 8.98 25.0 13.438 
520         
 50 1030 467 0.453 9.34 25.0 19.017 
1560         
 50 1037 491 0.473 9.82 25.0 24.289
Positive Control Cyclophosphamide 
 0.4       
 50 1052 740 0.703 14.80 25.0 84.648
Cyclophosphamide 
2.5       
 10 211 472 2.237 47.20 25.0 487.204
Trend: 3.278        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/18/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1061 507 0.478 10.14 26.0 0.000
Test Chemical Carbon tetrachloride 
1470         
 50 1048 495 0.472 9.90 26.0 -1.156 
1910         
 50 1050 528 0.503 10.56 26.0 5.233 
2930         
 50 1048 579 0.552 11.58 26.0 15.618
Positive Control Cyclophosphamide 
 0.4       
 50 1034 739 0.715 14.78 26.0 49.565
Cyclophosphamide 
2.5       
 10 206 377 1.830 37.70 26.0 282.985
Trend: 2.648        
Probability: 0.004