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Study Information
Study Attribute Value
CEBS Accession Number: 002-01833-0002-0000-9
Chemical Name: Carbon tetrachloride
CASRN: 56-23-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 398542_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/04/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Carbon tetrachloride 
300         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
1000         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
3000         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.3       
 200 40 0.200 12.0 9 0.045 3.5 21 0.105 9.0 10 0.050 1.0
Mitomycin-C 
5         
 25 33 1.320 52.0 13 0.520 44.0 10 0.400 20.0 10 0.400 1.0
Trend: 0.431 0.000 0.576  
Probability: 0.333 0.500 0.282  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/04/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Carbon tetrachloride 
300         
 200 9 0.045 4.0 2 0.010 1.0 7 0.035 3.0 0 0.000 0.0 
1000         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
3000         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 33 0.660 40.0 15 0.300 28.0 18 0.360 20.0 0 0.000 0.0
Trend: -0.412 0.008 -0.497  
Probability: 0.660 0.497 0.690