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Study Information
Study Attribute Value
CEBS Accession Number: 002-01835-0001-0000-0
Chemical Name: Carbromal
CASRN: 77-65-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 157167_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/13/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 423 0.410 8.46 25.5 0.000
Test Chemical Carbromal 
16.7       
 50 1043 419 0.402 8.38 25.5 -2.085 
50         
 50 1013 416 0.411 8.32 25.5 0.093 
166.7       
 50 1022 445 0.435 8.90 25.5 6.127 
500         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1030 562 0.546 11.24 25.5 32.990
Mitomycin-C 
 0.01      
 5 103 221 2.146 44.20 25.5 422.966
Trend: 0.950        
Probability: 0.171        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/13/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 414 0.404 8.28 25.5 0.000
Test Chemical Carbromal 
500         
 50 1031 428 0.415 8.56 25.5 2.780 
1666.7       
 50 993 473 0.476 9.46 25.5 17.933 
5000         
 50 1029 484 0.470 9.68 25.5 16.454
Positive Control Cyclophosphamide 
 0.4       
 50 1004 629 0.626 12.58 25.5 55.110
Cyclophosphamide 
2         
 5 98 160 1.633 32.00 25.5 304.220
Trend: 2.822        
Probability: 0.002