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Study Information
Study Attribute Value
CEBS Accession Number: 002-01835-0003-0000-2
Chemical Name: Carbromal
CASRN: 77-65-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 480465_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 451 0.432 9.02 27.5 0.000
Test Chemical Carbromal 
5         
 50 1040 460 0.442 9.20 27.5 2.486 
16         
 50 1043 506 0.485 10.12 27.5 12.410 
50         
 50 1038 432 0.416 8.64 27.5 -3.567 
160         
 50 1037 508 0.490 10.16 27.5 13.508 
500         
 0 0 0 0.000 0.00 27.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1044 583 0.558 11.66 27.5 29.392
Mitomycin-C 
 0.001     
 10 208 154 0.740 15.40 27.5 71.553
Trend: 1.379        
Probability: 0.084        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/14/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 405 0.386 8.10 26.0 0.000
Test Chemical Carbromal 
50         
 50 1041 435 0.418 8.70 26.0 8.233 
160         
 50 1049 469 0.447 9.38 26.0 15.802 
500         
 50 1038 453 0.436 9.06 26.0 13.037 
1600         
 50 1045 536 0.513 10.72 26.0 32.852
Positive Control Cyclophosphamide 
 0.3       
 50 1050 719 0.685 14.38 26.0 77.362
Trend: 4.203        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/06/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 423 0.404 8.46 26.0 0.000
Test Chemical Carbromal 
160         
 50 1049 417 0.398 8.34 26.0 -1.512 
500         
 50 1049 438 0.418 8.76 26.0 3.447 
800         
 50 1050 415 0.395 8.30 26.0 -2.078 
1200         
 50 1048 469 0.448 9.38 31.0 10.875 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.2       
 50 1048 923 0.881 18.46 26.0 118.203
Cyclophosphamide 
 0.6       
 10 211 299 1.417 29.90 26.0 251.083
Trend: 1.258        
Probability: 0.104