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Study Information
Study Attribute Value
CEBS Accession Number: 002-01835-0004-0000-3
Chemical Name: Carbromal
CASRN: 77-65-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 480465_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 10/02/1985    Harvest Time: 22 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Carbromal 
600         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
800         
 200 3 0.015 0.5 1 0.005 0.5 2 0.010 0.5 0 0.000 0.0 
1000         
 200 18 0.090 8.0 3 0.015 1.5 15 0.075 6.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 129 0.645 40.0 54 0.270 21.0 55 0.275 24.0 20 0.100 2.0
Mitomycin-C 
 0.125     
 50 108 2.160 80.0 55 1.100 64.0 33 0.660 38.0 20 0.400 2.0
Trend: 3.155 1.062 3.062  
Probability: 0.001 0.144 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/21/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Carbromal 
400         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
800         
 200 9 0.045 4.5 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0 
1200         
 200 17 0.085 7.0 10 0.050 4.5 7 0.035 3.0 0 0.000 0.0 
1600         
 103 112 1.087 47.6 21 0.204 16.5 71 0.689 43.7 20 0.194 2.0
Positive Control: Cyclophosphamide 
7.5       
 200 293 1.465 77.5 98 0.490 39.5 185 0.925 60.0 10 0.050 1.0
Cyclophosphamide 
15         
 50 164 3.280 98.0 36 0.720 58.0 78 1.560 76.0 50 1.000 5.0
Trend: 9.493 4.969 9.646  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 08/21/1985    Harvest Time: 22 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Carbromal 
600         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
800         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
1000         
 200 7 0.035 1.5 1 0.005 0.5 6 0.030 1.5 0 0.000 0.0 
1200         
 89 12 0.135 11.2 4 0.045 2.2 8 0.090 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 111 0.555 36.5 58 0.290 24.5 53 0.265 22.5 0 0.000 0.0
Trend: 2.951 1.375 2.766  
Probability: 0.002 0.085 0.003  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/26/1986    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Carbromal 
1000         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
1200         
 200 17 0.085 6.5 8 0.040 3.0 9 0.045 4.5 0 0.000 0.0 
1400         
 100 126 1.260 52.0 45 0.450 30.0 79 0.790 48.0 2 0.020 2.0
Positive Control: Cyclophosphamide 
2.5       
 200 52 0.260 22.5 21 0.105 10.0 31 0.155 13.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 40 0.800 48.0 16 0.320 22.0 24 0.480 40.0 0 0.000 0.0
Trend: 11.024 8.717 10.624  
Probability: 0.000 0.000 0.000