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Study Information
Study Attribute Value
CEBS Accession Number: 002-01836-0001-0000-1
Chemical Name: Carisoprodol
CASRN: 78-44-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 789521_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 07/14/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 321 0.308 6.42 26.0 3.449
Dimethyl Sulfoxide 
0         
 50 1040 310 0.298 6.20 26.0 0.000
Test Chemical Carisoprodol 
5         
 50 1048 415 0.396 8.30 26.0 32.849 
16         
 50 1046 404 0.386 8.08 26.0 29.575 
50         
 50 1050 335 0.319 6.70 26.0 7.035 
160         
 50 1047 281 0.268 5.62 26.0 -9.961 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1049 854 0.814 17.08 26.0 173.120
Mitomycin-C 
 0.005     
 50 1050 1131 1.077 22.62 26.0 261.364
Trend: -2.425        
Probability: 0.992        

Trial #: 2    Activation: No Activation    Date: 09/07/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 313 0.299 6.26 26.0 -28.252
Dimethyl Sulfoxide 
0         
 50 1044 435 0.417 8.70 26.0 0.000
Test Chemical Carisoprodol 
16         
 50 1045 411 0.393 8.22 26.0 -5.608 
50         
 50 1047 466 0.445 9.32 26.0 6.819 
160         
 50 1048 421 0.402 8.42 26.0 -3.588 
500         
 50 1046 474 0.453 9.48 26.0 8.757 
1000         
 0 0 0 0.000 0.00 26.0 N/A
Trend: 1.292        
Probability: 0.098        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/14/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 459 0.436 9.18 27.0 0.000
Negative (Not Specified) 
0         
 50 1048 446 0.426 8.92 27.0 -2.461
Test Chemical Carisoprodol 
5         
 50 1038 397 0.382 7.94 27.0 -12.341 
16         
 50 1047 361 0.345 7.22 27.0 -20.975 
50         
 50 1045 393 0.376 7.86 27.0 -13.806 
160         
 50 1041 365 0.351 7.30 27.0 -19.639 
500         
 50 1046 393 0.376 7.86 27.0 -13.888 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1048 1159 1.106 23.18 27.0 153.469
Cyclophosphamide 
1.5       
 50 1050 1148 1.093 22.96 27.0 150.585
Trend: -2.324        
Probability: 0.990        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/07/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 324 0.312 6.48 27.0 0.000
Negative (Not Specified) 
0         
 50 1044 333 0.319 6.66 27.0 2.187
Test Chemical Carisoprodol 
500         
 50 1039 397 0.382 7.94 27.0 22.413 
750         
 50 1043 352 0.337 7.04 27.0 8.121 
1000         
 50 1038 378 0.364 7.56 27.0 16.667 
1250         
 50 1042 422 0.405 8.44 27.0 29.747 
1500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1044 1445 1.384 28.90 27.0 343.425
Trend: 2.631        
Probability: 0.004