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Study Information
Study Attribute Value
CEBS Accession Number: 002-01841-0001-0000-7
Chemical Name: Castor oil
CASRN: 8001-79-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 154774_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/09/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 394 0.376 7.88 26.0 0.000
Test Chemical Castor oil 
160         
 50 1050 379 0.361 7.58 26.0 -3.899 
500         
 50 1049 429 0.409 8.58 26.0 8.883 
1600         
 50 1050 422 0.402 8.44 26.0 7.005 
5000         
 50 1050 430 0.410 8.60 26.0 9.033
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 509 0.486 10.18 26.0 29.311
Mitomycin-C 
 0.005     
 10 210 278 1.324 27.80 26.0 252.456
Trend: 1.780        
Probability: 0.038        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/09/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 404 0.385 8.08 26.0 0.000
Test Chemical Castor oil 
160         
 50 1050 402 0.383 8.04 26.0 -0.590 
500         
 50 1049 363 0.346 7.26 26.0 -10.149 
1600         
 50 1050 427 0.407 8.54 26.0 5.592 
5000         
 50 1049 399 0.380 7.98 26.0 -1.238
Positive Control Cyclophosphamide 
 0.1       
 50 1049 531 0.506 10.62 26.0 31.436
Cyclophosphamide 
 0.6       
 10 210 228 1.086 22.80 26.0 181.909
Trend: 0.244        
Probability: 0.404