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Study Information
Study Attribute Value
CEBS Accession Number: 002-01841-0002-0000-8
Chemical Name: Castor oil
CASRN: 8001-79-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 154774_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/07/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Castor oil 
1600         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
3000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
5000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 48 0.240 15.5 17 0.085 8.5 20 0.100 6.5 11 0.055 2.0
Mitomycin-C 
 0.25      
 50 16 0.320 26.0 6 0.120 10.0 10 0.200 18.0 0 0.000 0.0
Trend: -0.344 0.000 -0.344  
Probability: 0.634 0.000 0.634  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/07/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Castor oil 
1600         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
3000         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
5000         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 44 0.220 16.0 8 0.040 4.0 26 0.130 12.0 10 0.050 1.0
Cyclophosphamide 
7.5       
 50 18 0.360 30.0 3 0.060 6.0 15 0.300 28.0 0 0.000 0.0
Trend: 0.012 0.933 -0.578  
Probability: 0.495 0.175 0.718