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Study Information
Study Attribute Value
CEBS Accession Number: 002-01847-0001-0000-3
Chemical Name: Chloral hydrate
CASRN: 302-17-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 043571_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/11/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 488 0.470 9.76 26.0 0.000
Test Chemical Chloral hydrate 
16.7       
 50 1017 463 0.455 9.26 26.0 -3.071 
50         
 50 1040 520 0.500 10.40 26.0 6.455 
167         
 50 1042 747 0.717 14.94 26.0 52.633 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1040 635 0.611 12.70 26.0 29.998
Mitomycin-C 
 0.01      
 5 105 267 2.543 53.40 26.0 441.399
Trend: 7.824        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/04/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 415 0.399 8.30 26.0 0.000
Test Chemical Chloral hydrate 
100         
 50 1023 593 0.580 11.86 26.0 45.406 
150         
 50 1032 625 0.606 12.50 26.0 51.916 
200         
 50 1033 831 0.804 16.62 34.8 101.792 
350         
 0 0 0 0.000 0.00 34.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1035 515 0.498 10.30 26.0 24.816
Mitomycin-C 
 0.01      
 5 103 196 1.903 39.20 26.0 377.333
Trend: 11.437        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/11/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 464 0.448 9.28 26.0 0.000
Test Chemical Chloral hydrate 
167         
 50 1037 391 0.377 7.82 26.0 -15.814 
500         
 50 1017 386 0.380 7.72 26.0 -15.256 
1700         
 50 1040 567 0.545 11.34 26.0 21.728 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1042 651 0.625 13.02 26.0 39.494
Cyclophosphamide 
2         
 5 105 194 1.848 38.80 26.0 312.529
Trend: 3.341        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/04/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 365 0.351 7.30 26.0 0.000
Test Chemical Chloral hydrate 
3000         
 50 1030 504 0.489 10.08 26.0 39.423 
4000         
 50 1033 587 0.568 11.74 26.0 61.912 
5000         
 50 1036 712 0.687 14.24 34.8 95.822
Positive Control Cyclophosphamide 
 0.4       
 50 1020 629 0.617 12.58 26.0 75.708
Cyclophosphamide 
2         
 5 105 162 1.543 32.40 26.0 339.609
Trend: 10.791        
Probability: 0.000