Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01847-0002-0000-4
Chemical Name: Chloral hydrate
CASRN: 302-17-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 043571_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/12/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
750         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
1000         
 100 23 0.230 18.0 0 0.000 0.0 23 0.230 18.0 0 0.000 0.0 
1250         
 100 57 0.570 36.0 0 0.000 0.0 57 0.570 36.0 0 0.000 0.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 15 0.600 48.0 6 0.240 20.0 8 0.320 24.0 1 0.040 4.0
Trend: 7.259 -1.327 7.494  
Probability: 0.000 0.908 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/28/1984    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
2500         
 100 9 0.090 7.0 4 0.040 4.0 5 0.050 3.0 0 0.000 0.0 
3000         
 100 46 0.460 33.0 20 0.200 19.0 26 0.260 19.0 0 0.000 0.0 
3500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 13 0.130 10.0 3 0.030 3.0 9 0.090 7.0 1 0.010 1.0
Cyclophosphamide 
37.5       
 25 13 0.520 32.0 7 0.280 16.0 6 0.240 20.0 0 0.000 0.0
Trend: 6.112 5.087 4.147  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 10/30/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
400         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
600         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
800         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 23 0.230 13.0 14 0.140 11.0 9 0.090 7.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 28 1.120 36.0 12 0.480 24.0 6 0.240 16.0 10 0.400 4.0
Trend: 0.068 1.281 -0.453  
Probability: 0.473 0.100 0.675  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/31/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
3000         
 100 30 0.300 24.0 12 0.120 12.0 17 0.170 12.0 1 0.010 1.0 
3500         
 50 10 0.200 20.0 1 0.020 2.0 9 0.180 18.0 0 0.000 0.0 
4000         
 25 8 0.320 24.0 1 0.040 4.0 7 0.280 20.0 0 0.000 0.0 
4500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 14 0.140 11.0 9 0.090 7.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 14 0.560 28.0 5 0.200 16.0 7 0.280 16.0 2 0.080 4.0
Trend: 3.646 0.452 4.088  
Probability: 0.000 0.326 0.000