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Study Information
Study Attribute Value
CEBS Accession Number: 002-01847-0002-0000-4
Chemical Name: Chloral hydrate
CASRN: 302-17-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 043571_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/12/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
750         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
1000         
 100 23 0.230 18.0 0 0.000 0.0 23 0.230 18.0 0 0.000 0.0 
1250         
 100 57 0.570 36.0 0 0.000 0.0 57 0.570 36.0 0 0.000 0.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 15 0.600 48.0 6 0.240 20.0 8 0.320 24.0 1 0.040 4.0
Trend: 7.259 -1.327 7.494  
Probability: 0.000 0.908 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/28/1984    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
2500         
 100 9 0.090 7.0 4 0.040 4.0 5 0.050 3.0 0 0.000 0.0 
3000         
 100 46 0.460 33.0 20 0.200 19.0 26 0.260 19.0 0 0.000 0.0 
3500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 13 0.130 10.0 3 0.030 3.0 9 0.090 7.0 1 0.010 1.0
Cyclophosphamide 
37.5       
 25 13 0.520 32.0 7 0.280 16.0 6 0.240 20.0 0 0.000 0.0
Trend: 6.112 5.087 4.147  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 10/30/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
400         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
600         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
800         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 23 0.230 13.0 14 0.140 11.0 9 0.090 7.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 28 1.120 36.0 12 0.480 24.0 6 0.240 16.0 10 0.400 4.0
Trend: 0.068 1.281 -0.453  
Probability: 0.473 0.100 0.675  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/31/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chloral hydrate 
3000         
 100 30 0.300 24.0 12 0.120 12.0 17 0.170 12.0 1 0.010 1.0 
3500         
 50 10 0.200 20.0 1 0.020 2.0 9 0.180 18.0 0 0.000 0.0 
4000         
 25 8 0.320 24.0 1 0.040 4.0 7 0.280 20.0 0 0.000 0.0 
4500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 14 0.140 11.0 9 0.090 7.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 14 0.560 28.0 5 0.200 16.0 7 0.280 16.0 2 0.080 4.0
Trend: 3.646 0.452 4.088  
Probability: 0.000 0.326 0.000