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Study Information
Study Attribute Value
CEBS Accession Number: 002-01848-0001-0000-4
Chemical Name: Chloramben
CASRN: 133-90-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 783500_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 08/07/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 484 0.463 9.68 26.0 0.000
Test Chemical Chloramben 
50         
 50 1041 481 0.462 9.62 26.0 -0.143 
166.7       
 50 1041 748 0.719 14.96 26.0 55.288 
500         
 50 1040 902 0.867 18.04 26.0 87.439 
1700         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 602 0.574 12.04 26.0 24.143
Mitomycin-C 
 0.01      
 5 104 222 2.135 44.40 26.0 361.324
Trend: 13.386        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 524 258 0.492 10.32 26.0 0.000
Test Chemical Chloramben 
1500         
 25 518 822 1.587 32.88 35.0 222.295 
1760         
 25 519 915 1.763 36.60 35.0 258.068 
2000         
 25 511 966 1.890 38.64 35.0 283.944
Positive Control Mitomycin-C 
 0.001     
 25 521 359 0.689 14.36 26.0 39.949
Mitomycin-C 
 0.01      
 5 105 260 2.476 52.00 26.0 402.916
Trend: 18.762        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/07/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 465 0.445 9.30 26.0 0.000
Test Chemical Chloramben 
500         
 50 1038 422 0.407 8.44 26.0 -8.723 
1700         
 50 1046 457 0.437 9.14 26.0 -1.908 
5000         
 50 1046 908 0.868 18.16 26.0 94.895
Positive Control Cyclophosphamide 
 0.4       
 50 1048 822 0.784 16.44 26.0 76.099
Cyclophosphamide 
2         
 5 104 200 1.923 40.00 26.0 331.762
Trend: 12.566        
Probability: 0.000