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Study Information
Study Attribute Value
CEBS Accession Number: 002-01848-0002-0000-5
Chemical Name: Chloramben
CASRN: 133-90-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 783500_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/25/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chloramben 
1990         
 50 11 0.220 18.0 4 0.080 8.0 6 0.120 12.0 1 0.020 2.0 
2260         
 25 26 1.040 56.0 5 0.200 16.0 21 0.840 52.0 0 0.000 0.0 
2490         
 10 12 1.200 80.0 4 0.400 40.0 8 0.800 60.0 0 0.000 0.0 
2760         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 50 13 0.260 24.0 6 0.120 12.0 7 0.140 12.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 18 0.720 44.0 11 0.440 28.0 7 0.280 20.0 0 0.000 0.0
Trend: 6.949 4.038 6.312  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/30/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 9 0.090 6.0 2 0.020 2.0 7 0.070 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chloramben 
3000         
 100 7 0.070 7.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
4000         
 100 17 0.170 15.0 8 0.080 8.0 9 0.090 9.0 0 0.000 0.0 
4500         
 100 11 0.110 11.0 6 0.060 6.0 5 0.050 5.0 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 12 0.120 9.0 4 0.040 4.0 8 0.080 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 9 0.360 24.0 8 0.320 24.0 1 0.040 4.0 0 0.000 0.0
Trend: 3.273 2.520 2.215  
Probability: 0.001 0.006 0.013  


Trial #:2   Activation: No Activation    Date: 08/30/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chloramben 
1510         
 100 21 0.210 16.0 4 0.040 4.0 17 0.170 13.0 0 0.000 0.0 
2040         
 100 22 0.220 16.0 4 0.040 4.0 18 0.180 13.0 0 0.000 0.0 
2260         
 100 21 0.210 15.0 6 0.060 6.0 14 0.140 10.0 1 0.010 1.0 
2490         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 14 0.140 12.0 5 0.050 5.0 9 0.090 8.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 15 0.600 48.0 10 0.400 32.0 5 0.200 16.0 0 0.000 0.0
Trend: 2.412 1.273 2.120  
Probability: 0.008 0.101 0.017