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Study Information
Study Attribute Value
CEBS Accession Number: 002-01852-0001-0000-9
Chemical Name: Chloramphenicol sodium succinate
CASRN: 982-57-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 852970_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
No Activation  3  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/03/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 389 0.374 7.78 26.0 0.000
Negative (Not Specified) 
0         
 50 1030 360 0.350 7.20 26.0 -6.467
Test Chemical Chloramphenicol sodium succinate 
16         
 50 1043 435 0.417 8.70 26.0 11.611 
50         
 50 1044 485 0.465 9.70 26.0 24.320 
160         
 50 1045 475 0.455 9.50 26.0 21.641 
500         
 50 1044 493 0.472 9.86 26.0 26.371 
1600         
 50 1043 509 0.488 10.18 26.0 30.597 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1024 1461 1.427 29.22 26.0 281.814
Trend: 4.201        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/29/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 427 0.413 8.54 26.0 0.000
Negative (Not Specified) 
0         
 50 1015 404 0.398 8.08 26.0 -3.615
Test Chemical Chloramphenicol sodium succinate 
2000         
 50 1027 561 0.546 11.22 26.0 32.277 
3000         
 50 1014 606 0.598 12.12 26.0 44.720 
4000         
 0 0 0 0.000 0.00 26.0 N/A 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1028 1620 1.576 32.40 26.0 281.605
Trend: 5.672        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 10/08/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 0 0 0 0.000 0.00 35.0 N/A
Dimethyl Sulfoxide 
0         
 0 0 0 0.000 0.00 35.0 N/A
Test Chemical Chloramphenicol sodium succinate 
500         
 50 1032 535 0.518 10.70 35.0 0.000 
1000         
 50 1046 665 0.636 13.30 35.0 0.000 
2000         
 50 1041 660 0.634 13.20 35.0 0.000 
3000         
 50 1045 695 0.665 13.90 35.0 0.000 
4000         
 50 1036 668 0.645 13.36 35.0 0.000 
5000         
 50 1041 931 0.894 18.62 35.0 0.000
Positive Control Chloramphenicol sodium succinate 
 0         
 0 0 0 0.000 0.00 35.0 N/A
Trend: 8.405        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/03/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1028 416 0.405 8.32 26.0 -0.592
Dimethyl Sulfoxide 
0         
 50 1017 414 0.407 8.28 26.0 0.000
Test Chemical Chloramphenicol sodium succinate 
16         
 50 1036 401 0.387 8.02 26.0 -4.916 
50         
 50 1027 413 0.402 8.26 26.0 -1.213 
500         
 50 1035 429 0.414 8.58 26.0 1.821 
1600         
 50 1035 408 0.394 8.16 26.0 -3.163 
5000         
 50 1025 441 0.430 8.82 26.0 5.690
Positive Control Cyclophosphamide 
2         
 50 1026 2473 2.410 49.46 26.0 492.103
Trend: 0.887        
Probability: 0.188        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1027 366 0.356 7.32 26.0 -10.116
Dimethyl Sulfoxide 
0         
 50 1024 406 0.396 8.12 26.0 0.000
Test Chemical Chloramphenicol sodium succinate 
2000         
 50 1028 401 0.390 8.02 26.0 -1.616 
3000         
 50 1024 404 0.395 8.08 26.0 -0.493 
4000         
 50 1032 422 0.409 8.44 26.0 3.135 
5000         
 50 1006 418 0.416 8.36 26.0 4.798
Positive Control Cyclophosphamide 
1.5       
 50 1030 2089 2.028 41.78 26.0 411.535
Trend: 0.876        
Probability: 0.190