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Study Information
Study Attribute Value
CEBS Accession Number: 002-01855-0001-0000-2
Chemical Name: Chlordecone (kepone)
CASRN: 143-50-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 232320_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/05/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 411 0.395 8.22 25.8 0.000
Test Chemical Chlordecone (kepone) 
 0.5       
 50 1043 462 0.443 9.24 29.3 12.085 
1.67      
 50 1028 615 0.598 12.30 29.3 51.382 
5         
 50 1030 573 0.556 11.46 32.8 40.770
Positive Control Mitomycin-C 
 0.005     
 50 1036 1380 1.332 27.60 25.8 237.063
Trend: 6.580        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/09/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 411 0.401 8.22 25.5 0.000
Test Chemical Chlordecone (kepone) 
5         
 50 1010 550 0.545 11.00 25.5 35.807 
7.5       
 50 1037 495 0.477 9.90 25.5 19.044 
10         
 50 1019 756 0.742 15.12 32.0 85.025
Positive Control Mitomycin-C 
 0.005     
 25 518 725 1.400 29.00 25.5 249.052
Trend: 8.892        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/05/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 391 0.375 7.82 25.8 0.000
Test Chemical Chlordecone (kepone) 
1.67      
 50 1042 386 0.370 7.72 25.8 -1.184 
5         
 50 1048 424 0.405 8.48 25.8 7.923
Positive Control Cyclophosphamide 
1.5       
 50 1046 1660 1.587 33.20 25.8 323.335
Trend: 1.098        
Probability: 0.136        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/14/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 412 0.397 8.24 26.0 0.000
Test Chemical Chlordecone (kepone) 
10.13      
 50 1045 409 0.391 8.18 26.0 -1.393 
12.38      
 50 1039 425 0.409 8.50 26.0 3.056 
15         
 50 1048 464 0.443 9.28 26.0 11.547 
20         
 0 0 0 0.000 0.00 0.0 N/A 
25         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1045 1237 1.184 24.74 26.0 198.232
Trend: 1.715        
Probability: 0.043