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Study Information
Study Attribute Value
CEBS Accession Number: 002-01855-0003-0000-4
Chemical Name: Chlordecone alcohol
CASRN: 1034-41-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 873104_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/17/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 462 0.441 9.24 26.0 0.000
Test Chemical Chlordecone alcohol 
 0.16      
 50 1050 441 0.420 8.82 26.0 -4.818 
 0.5       
 50 1050 420 0.400 8.40 26.0 -9.351 
1.6       
 50 1050 408 0.389 8.16 26.0 -11.941 
5         
 50 1050 419 0.399 8.38 26.0 -9.566
Positive Control Mitomycin-C 
 0.005     
 25 523 518 0.990 20.72 26.0 124.457
Trend: -1.853        
Probability: 0.968        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/17/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 473 0.453 9.46 26.0 0.000
Test Chemical Chlordecone alcohol 
 0.5       
 50 1049 510 0.486 10.20 26.0 7.411 
1.6       
 50 1049 493 0.470 9.86 26.0 3.831 
5         
 50 1046 552 0.528 11.04 26.0 16.590 
16         
 50 1048 538 0.513 10.76 26.0 13.416
Positive Control Cyclophosphamide 
1         
 50 1048 763 0.728 15.26 26.0 60.849
Trend: 2.377        
Probability: 0.009        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/10/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 404 0.387 8.08 26.0 0.000
Test Chemical Chlordecone alcohol 
2         
 50 1041 422 0.405 8.44 26.0 4.857 
4         
 50 1045 422 0.404 8.44 26.0 4.455 
8         
 50 1046 405 0.387 8.10 26.0 0.152 
16         
 50 1046 469 0.448 9.38 26.0 15.978
Positive Control Cyclophosphamide 
1.5       
 50 1049 1355 1.292 27.10 26.0 234.117
Trend: 1.691        
Probability: 0.045