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Study Information
Study Attribute Value
CEBS Accession Number: 002-01855-0004-0000-5
Chemical Name: Chlordecone alcohol
CASRN: 1034-41-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 873104_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/17/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Chlordecone alcohol 
1.6       
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
5         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
16         
 100 9 0.090 9.0 1 0.010 1.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 27 0.270 23.0 8 0.080 8.0 19 0.190 16.0 0 0.000 0.0
Trend: 1.272 -0.002 1.440  
Probability: 0.102 0.501 0.075  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/10/1982    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlordecone alcohol 
4         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
8         
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0 
16         
 100 11 0.110 10.0 4 0.040 4.0 7 0.070 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 25 0.250 22.0 9 0.090 9.0 16 0.160 14.0 0 0.000 0.0
Trend: 2.228 1.278 1.787  
Probability: 0.013 0.101 0.037  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/17/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Chlordecone alcohol 
1.6       
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
5         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
16         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 18 0.180 13.0 4 0.040 4.0 14 0.140 10.0 0 0.000 0.0
Trend: 0.355 0.258 0.265  
Probability: 0.361 0.398 0.395