Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01856-0001-0000-3
Chemical Name: Chlorendic acid
CASRN: 115-28-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 179071_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/31/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 415 0.402 8.30 26.5 0.000
Negative (Not Specified) 
0         
 50 1043 407 0.390 8.14 26.5 -2.962
Test Chemical Chlorendic acid 
16         
 50 1038 428 0.412 8.56 26.5 2.536 
50         
 50 1028 399 0.388 7.98 26.5 -3.481 
160         
 50 1028 420 0.409 8.40 26.5 1.599 
500         
 50 1034 444 0.429 8.88 26.5 6.781 
1600         
 0 0 0 0.000 0.00 33.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1023 751 0.734 15.02 26.5 82.556
Mitomycin-C 
 0.01      
 10 205 487 2.376 48.70 26.5 490.754
Trend: 0.809        
Probability: 0.209        

Trial #: 2    Activation: No Activation    Date: 06/12/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 405 0.391 8.10 27.0 0.151
Dimethyl Sulfoxide 
0         
 50 1035 404 0.390 8.08 27.0 0.000
Test Chemical Chlorendic acid 
500         
 50 1047 522 0.499 10.44 32.0 27.727 
1000         
 50 1046 559 0.534 11.18 27.0 36.911 
1000         
 50 1038 531 0.512 10.62 32.0 31.056 
1500         
 50 1043 519 0.498 10.38 27.0 27.480 
2000         
 50 1043 550 0.527 11.00 32.0 35.094 
2000         
 0 0 0 0.000 0.00 27.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1050 929 0.885 18.58 27.0 126.665
Mitomycin-C 
 0.01      
 10 209 692 3.311 69.20 27.0 748.240
Trend: 3.921        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/31/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 445 0.427 8.90 26.0 -10.565
Dimethyl Sulfoxide 
0         
 50 1044 499 0.478 9.98 26.0 0.000
Test Chemical Chlorendic acid 
50         
 50 1042 468 0.449 9.36 26.0 -6.032 
160         
 50 1037 437 0.421 8.74 26.0 -11.834 
500         
 50 1044 448 0.429 8.96 26.0 -10.220 
1600         
 50 1044 449 0.430 8.98 26.0 -10.020
Positive Control Cyclophosphamide 
 0.3       
 50 1046 729 0.697 14.58 26.0 45.813
Cyclophosphamide 
2         
 10 208 317 1.524 31.70 26.0 218.857
Trend: -1.783        
Probability: 0.963        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/08/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 469 0.452 9.38 26.0 0.000
Negative (Not Specified) 
0         
 50 1026 488 0.476 9.76 26.0 5.268
Test Chemical Chlorendic acid 
500         
 50 1048 407 0.388 8.14 26.0 -14.048 
1000         
 50 1032 429 0.416 8.58 26.0 -7.997 
1500         
 50 1041 459 0.441 9.18 26.0 -2.414 
2000         
 50 1037 462 0.446 9.24 26.0 -1.398
Positive Control Cyclophosphamide 
 0.3       
 50 1044 622 0.596 12.44 26.0 31.860
Cyclophosphamide 
2         
 10 210 319 1.519 31.90 26.0 236.199
Trend: 0.575        
Probability: 0.283