COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01856-0002-0000-4
Chemical Name: Chlorendic acid
CASRN: 115-28-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 179071_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Weakly Positive 
Induced Rat Liver S9  2_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 02/03/1984    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Chlorendic acid
50         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
160         
100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
500         
100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
1600         
100 8 0.080 6.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 34 0.340 26.0 8 0.080 7.0 26 0.260 22.0 0 0.000 0.0
Mitomycin-C
1         
50 19 0.380 30.0 7 0.140 14.0 12 0.240 18.0 0 0.000 0.0
Trend: 1.615 1.355 1.655  
Probability: 0.053 0.088 0.049  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/02/1984    Harvest Time: 11.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 4 0.040 4.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: Chlorendic acid
50         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
160         
100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
500         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
1600         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 20 0.200 16.0 10 0.100 10.0 10 0.100 7.0 0 0.000 0.0
Cyclophosphamide
50         
50 27 0.540 30.0 16 0.320 26.0 11 0.220 12.0 0 0.000 0.0
Trend: -1.077 0.355 -1.272  
Probability: 0.859 0.361 0.898  


Trial #:2   Activation: No Activation    Date: 03/22/1984    Harvest Time: 11.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorendic acid
1600         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
3000         
100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
4000         
100 9 0.090 9.0 1 0.010 1.0 6 0.060 6.0 2 0.020 2.0
5000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 22 0.220 20.0 8 0.080 8.0 14 0.140 13.0 0 0.000 0.0
Mitomycin-C
1         
50 17 0.340 26.0 8 0.160 14.0 9 0.180 16.0 0 0.000 0.0
Trend: 2.394 -0.383 2.303  
Probability: 0.008 0.649 0.011  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/22/1984    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified)
0         
100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chlorendic acid
1600         
100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
3000         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
4000         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
5000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 23 0.230 19.0 12 0.120 10.0 11 0.110 10.0 0 0.000 0.0
Cyclophosphamide
50         
50 61 1.220 70.0 24 0.480 36.0 37 0.740 50.0 0 0.000 0.0
Trend: -0.110 0.464 -0.396  
Probability: 0.544 0.321 0.654