Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01856-0009-0000-1 |
Chemical Name: | Chlorendic acid |
CASRN: | 115-28-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 197818 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 77 | 111 | 99 | 43 | 40 |
64 | 75 | 68 | 36 | ||||
77 | 93 | 74 | 32 | ||||
73 | 121 | 112 | 51 | ||||
Test Chemical | Chlorendic acid | 62.5 | 73 | 102 | 86 | 39 | 40 |
90 | 129 | 109 | 41 | ||||
125 | 71 | 123 | 95 | 45 | 40 | ||
82 | 127 | 87 | 35 | ||||
250 | 88 | 83 | 68 | 26 | 33 | ||
86 | 121 | 103 | 40 | ||||
500 | 81 | 133 | 94 | 39 | 38 | ||
86 | 117 | 94 | 36 | ||||
1000 | 82 | 93 | 103 | 42 | 33 | ||
81 | 79 | 57 | 23 | ||||
2000 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 32 | 19 | 278 | 294 | 291* |
31 | 33 | 264 | 287 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 49r | 59 | 113 | 77 | 39 |
103 | 120 | 69 | 22 | ||||
42r | 72 | 50 | 39 | ||||
58 | 80 | 96 | 55 | ||||
Test Chemical | Chlorendic acid | 700 | 42 | 57 | 67 | 53 | 60 |
34 | 39 | 67 | 66 | ||||
900 | 48 | 40 | 90 | 62 | 59 | ||
62# | 56 | 103 | 55 | ||||
1100 | 59 | 35 | 91 | 51 | 53 | ||
46 | 33 | 75 | 54 | ||||
1300 | 57 | 23 | 108 | 64 | 66* | ||
65 | 56 | 131 | 68 | ||||
1500 | 47 | 22 | 149 | 105 | 125* | ||
49 | 18 | 210 | 144 | ||||
1700 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 17 | 14 | 250 | 495 | 522* |
11 | 10 | 181 | 548 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 92 | 96 | 142 | 52 | 50 |
79 | 102 | 116 | 49 | ||||
94 | 94 | 127 | 45 | ||||
67 | 108 | 105 | 52 | ||||
Test Chemical | Chlorendic acid | 700 | 73 | 80 | 156 | 71 | 74 |
68 | 81 | 156 | 77 | ||||
900 | 152r | 78 | 224 | 49 | |||
94 | 60 | 140 | 50 | ||||
1100 | 81 | 69 | 111 | 46 | 46 | ||
79 | 67 | 107 | 45 | ||||
1300 | 55 | 60 | 91 | 55 | 49 | ||
85 | 60 | 109 | 43 | ||||
1500 | 100 | 59 | 157 | 52 | 55 | ||
97 | 34 | 167 | 57 | ||||
1700 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 32 | 21 | 410 | 434 | 416* |
33 | 20 | 392 | 398 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 105 | 88 | 75 | 24 | 35 |
114 | 107 | 112 | 33 | ||||
98 | 99 | 134 | 46 | ||||
109 | 106 | 118 | 36 | ||||
Test Chemical | Chlorendic acid | 1300 | 94 | 66 | 96 | 34 | 36 |
98 | 71 | 109 | 37 | ||||
1400 | 104 | 49 | 139 | 44 | 38 | ||
119 | 76 | 113 | 32 | ||||
1500 | 117 | 69 | 131 | 37 | 40 | ||
93 | 69 | 121 | 43 | ||||
1600 | 113 | 73 | 113 | 33 | 38 | ||
91 | 75 | 116 | 43 | ||||
1700 | 55 | 4 | 520 | 315 | 287* | ||
77 | 6 | 598 | 258 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 69 | 34 | 520 | 253 | 300* |
60 | 33 | 628 | 347 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination