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Study Information
Study Attribute Value
CEBS Accession Number: 002-01858-0001-0000-5
Chemical Name: Chlorinated paraffins: C12, 60% chlorine
CASRN: 108171-26-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 132281_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/21/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1050 458 0.436 9.16 26.8 0.000
Test Chemical Chlorinated paraffins: C12, 60% chlorine 
 0.5       
 50 1050 489 0.466 9.78 26.8 6.769 
5         
 50 1048 536 0.511 10.72 26.8 17.254 
5000         
 50 1050 756 0.720 15.12 32.1 65.066
Positive Control Mitomycin-C 
 0.001     
 50 1050 600 0.571 12.00 26.8 31.004
Mitomycin-C 
 0.01      
 5 105 263 2.505 52.60 26.8 474.236
Trend: 9.417        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 25 523 216 0.413 8.64 25.8 0.000
Test Chemical Chlorinated paraffins: C12, 60% chlorine 
5         
 25 524 340 0.649 13.60 25.8 57.107 
1700         
 25 521 391 0.750 15.64 32.3 81.713 
5000         
 25 516 368 0.713 14.72 32.3 72.682
Positive Control Mitomycin-C 
 0.001     
 25 521 357 0.685 14.28 25.8 65.912
Mitomycin-C 
 0.01      
 5 105 191 1.819 38.20 25.8 340.445
Trend: 6.820        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/21/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1050 399 0.380 7.98 26.8 0.000
Test Chemical Chlorinated paraffins: C12, 60% chlorine 
5         
 50 1049 556 0.530 11.12 26.8 39.481 
500         
 5 106 79 0.745 15.80 26.8 96.127 
1700         
 50 1047 680 0.649 13.60 26.8 70.914 
5000         
 50 1045 628 0.601 12.56 26.8 58.147
Positive Control Cyclophosphamide 
 0.4       
 50 1050 721 0.687 14.42 26.8 80.702
Cyclophosphamide 
2         
 5 104 198 1.904 39.60 26.8 401.012
Trend: 8.296        
Probability: 0.000