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Study Information
Study Attribute Value
CEBS Accession Number: 002-01858-0002-0000-6
Chemical Name: Chlorinated paraffins: C12, 60% chlorine
CASRN: 108171-26-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 132281_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 12/02/1986    Harvest Time: 20.2 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Acetone 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Chlorinated paraffins: C12, 60% chlorine 
1250         
 200 4 0.020 2.0 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 
2500         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 17 0.085 8.5 7 0.035 3.5 8 0.040 4.0 2 0.010 1.0
Positive Control: Mitomycin-C 
 0.05      
 200 13 0.065 6.5 6 0.030 3.0 6 0.030 3.0 1 0.005 0.5
Mitomycin-C 
 0.08      
 25 14 0.560 48.0 4 0.160 16.0 9 0.360 28.0 1 0.040 4.0
Trend: 3.522 1.765 3.148  
Probability: 0.000 0.039 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/02/1986    Harvest Time: 12.1 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 1 0.005 0.5 1 0.005 0.5
Acetone 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorinated paraffins: C12, 60% chlorine 
2513         
 200 8 0.040 4.0 2 0.010 1.0 3 0.015 1.5 3 0.015 1.5 
3750         
 200 4 0.020 2.0 0 0.000 0.0 2 0.010 1.0 2 0.010 1.0 
5000         
 200 8 0.040 3.5 3 0.015 1.5 4 0.020 1.5 1 0.005 0.5
Positive Control: Cyclophosphamide 
7.5       
 200 32 0.160 14.0 9 0.045 4.5 23 0.115 9.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 18 0.720 48.0 8 0.320 28.0 10 0.400 28.0 0 0.000 0.0
Trend: 0.713 0.632 0.257  
Probability: 0.238 0.264 0.399  


Trial #:2   Activation: No Activation    Date: 01/21/1987    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Acetone 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Chlorinated paraffins: C12, 60% chlorine 
3784         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
4400         
 100 8 0.080 6.0 1 0.010 1.0 7 0.070 5.0 0 0.000 0.0 
5000         
 100 12 0.120 10.0 1 0.010 1.0 11 0.110 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 29 0.290 25.0 12 0.120 12.0 17 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 16 0.640 52.0 7 0.280 24.0 9 0.360 32.0 0 0.000 0.0
Trend: 2.536 0.781 2.401  
Probability: 0.006 0.217 0.008