Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01858-0013-0000-8
Chemical Name:	Chlorinated paraffins: C12, 60% chlorine
CASRN:	108171-26-2
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	333321
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Acetone	0	105	105	65	21	19
			103	100	60	20
			113	92	73	22
			90	103	38	14
Test Chemical	Chlorinated paraffins: C12, 60% chlorine	24	101	96	91	30	24
			90	96	47	17	24
		36	78	67	71	30	26
			103	73	69	22	26
		48	81	30	103	42	38*
			75	31	77	34	38*
		60	56	10	103	62	56*
			99	15	147	50	56*
		72	48	6	90	63	64*
			73	10	143	65	64*
Positive Control	Methyl Methane Sulfonate	15	43	42	166	129	126*
Positive Control			44	36	162	122	126*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Acetone	0	79	99	68	29	31
			58	95	37	21
			77	105	101	44
Test Chemical	Chlorinated paraffins: C12, 60% chlorine	12	70	86	72	34	32
			89	90	79	29	32
		24	65	60	61	31	38
			63	63	86	45	38
		36	84	66	74	29	38
			76	49	108	47	38
		48	87	23	108	42	37
			84	25	81	32	37
		60	52	12	139	89	102*
			56	13	193	115	102*
		72

Positive Control	Methyl Methane Sulfonate	15	54	50	266	164	154*
Positive Control			47	37	202	143	154*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination