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Study Information
Study Attribute Value
CEBS Accession Number: 002-01858-0013-0000-8
Chemical Name: Chlorinated paraffins: C12, 60% chlorine
CASRN: 108171-26-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 333321
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Acetone 
 0         
 105 105 65 21 19
    103 100 60 20
    113 92 73 22
    90 103 38 14
Test Chemical Chlorinated paraffins: C12, 60% chlorine 
24         
 101 96 91 30 24
    90 96 47 17
  
36         
 78 67 71 30 26
    103 73 69 22
  
48         
 81 30 103 42 38*
    75 31 77 34
  
60         
 56 10 103 62 56*
    99 15 147 50
  
72         
 48 6 90 63 64*
    73 10 143 65
Positive Control Methyl Methane Sulfonate 
15         
 43 42 166 129 126*
    44 36 162 122

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Acetone 
 0         
 79 99 68 29 31
    58 95 37 21
    77 105 101 44
Test Chemical Chlorinated paraffins: C12, 60% chlorine 
12         
 70 86 72 34 32
    89 90 79 29
  
24         
 65 60 61 31 38
    63 63 86 45
  
36         
 84 66 74 29 38
    76 49 108 47
  
48         
 87 23 108 42 37
    84 25 81 32
  
60         
 52 12 139 89 102*
    56 13 193 115
  
72         
   
Positive Control Methyl Methane Sulfonate 
15         
 54 50 266 164 154*
    47 37 202 143

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination