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Study Information
Study Attribute Value
CEBS Accession Number: 002-01859-0001-0000-6
Chemical Name: Chlorinated trisodium phosphate
CASRN: 56802-99-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 387936_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/10/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 368 0.353 7.36 26.0 0.000
Test Chemical Chlorinated trisodium phosphate 
60         
 50 1029 379 0.368 7.58 26.0 4.390 
200         
 50 1047 385 0.368 7.70 26.0 4.220 
600         
 50 1043 448 0.430 8.96 26.0 21.739
Positive Control Mitomycin-C 
 0.002     
 50 1037 583 0.562 11.66 26.0 59.341
Mitomycin-C 
 0.01      
 10 210 343 1.633 34.30 26.0 362.926
Trend: 2.663        
Probability: 0.004        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 460 0.440 9.20 26.0 0.000
Test Chemical Chlorinated trisodium phosphate 
600         
 50 1047 501 0.479 10.02 26.0 8.705 
2000         
 50 1032 725 0.703 14.50 26.0 59.594 
4000         
 50 1045 1153 1.103 23.06 26.0 150.652
Positive Control Cyclophosphamide 
 0.5       
 50 1041 749 0.720 14.98 26.0 63.452
Cyclophosphamide 
2.5       
 10 211 396 1.877 39.60 26.0 326.355
Trend: 18.898        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/24/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 478 0.458 9.56 26.0 0.000
Test Chemical Chlorinated trisodium phosphate 
2000         
 50 1037 662 0.638 13.24 26.0 39.295 
3000         
 50 1024 929 0.907 18.58 26.0 97.958 
4000         
 50 1038 973 0.937 19.46 30.0 104.537
Positive Control Cyclophosphamide 
 0.5       
 50 1046 684 0.654 13.68 26.0 42.686
Cyclophosphamide 
2.5       
 10 209 307 1.469 30.70 26.0 220.515
Trend: 14.558        
Probability: 0.000