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Study Information
Study Attribute Value
CEBS Accession Number: 002-01859-0002-0000-7
Chemical Name: Chlorinated trisodium phosphate
CASRN: 56802-99-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 387936_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #:1   Activation: No Activation    Date: 07/31/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chlorinated trisodium phosphate 
200         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
800         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
2000         
 100 3 0.030 1.0 0 0.000 0.0 3 0.030 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 100 35 0.350 29.0 13 0.130 12.0 22 0.220 19.0 0 0.000 0.0
Trend: 0.439 -0.482 0.786  
Probability: 0.330 0.685 0.216  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/03/1984    Harvest Time: 18 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorinated trisodium phosphate 
2000         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
3000         
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
4000         
 100 29 0.290 18.0 13 0.130 11.0 16 0.160 12.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 127 1.270 52.0 49 0.490 36.0 28 0.280 23.0 50 0.500 5.0
Trend: 3.999 3.242 3.545  
Probability: 0.000 0.001 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/20/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorinated trisodium phosphate 
3000         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
3500         
 100 9 0.090 9.0 2 0.020 2.0 7 0.070 7.0 0 0.000 0.0 
4000         
 100 11 0.110 10.0 3 0.030 2.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 70 0.700 41.0 35 0.350 29.0 25 0.250 17.0 10 0.100 1.0
Trend: 2.695 0.743 2.642  
Probability: 0.004 0.229 0.004  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 07/31/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 5.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: Chlorinated trisodium phosphate 
400         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
2000         
 100 15 0.150 15.0 0 0.000 0.0 15 0.150 15.0 0 0.000 0.0 
3000         
 100 20 0.200 19.0 1 0.010 1.0 19 0.190 19.0 0 0.000 0.0 
4000         
 100 53 0.530 35.0 6 0.060 6.0 47 0.470 32.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 64 0.640 45.0 39 0.390 31.0 25 0.250 21.0 0 0.000 0.0
Trend: 6.856 2.345 6.527  
Probability: 0.000 0.010 0.000