Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01863-0011-0000-2 |
Chemical Name: | Chlorobenzene |
CASRN: | 108-90-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 103069 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 97 | 99 | 111 | 38 | 30 |
97 | 92 | 103 | 36 | ||||
86 | 99 | 53 | 20 | ||||
111 | 110 | 88 | 27 | ||||
Test Chemical | Chlorobenzene | 6.25 | 97 | 99 | 113 | 39 | 43 |
92 | 85 | 128 | 46 | ||||
12.5 | 88 | 94 | 78 | 30 | 34 | ||
95 | 93 | 108 | 38 | ||||
25 | 81 | 69 | 78 | 32 | 34 | ||
75 | 75 | 80 | 36 | ||||
50 | 80 | 66 | 82 | 34 | 34 | ||
79 | 74 | 78 | 33 | ||||
100 | 64 | 52 | 66 | 34 | 33 | ||
68 | 55 | 64 | 31 | ||||
200 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 29 | 19 | 242 | 278 | 261* |
32 | 18 | 236 | 243 | ||||
Methyl Methane Sulfonate | 250 | 73 | 68 | 273 | 125 | 131* | |
82 | 61 | 337 | 137 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 80 | 90 | 100 | 42 | 41 |
85 | 95 | 114 | 45 | ||||
91 | 108 | 129 | 47 | ||||
100 | 107 | 96 | 32 | ||||
Test Chemical | Chlorobenzene | 50 | 87 | 73 | 126 | 48 | 48 |
79 | 66 | 112 | 47 | ||||
75 | 94 | 73 | 142 | 50 | 48 | ||
99 | 57 | 133 | 45 | ||||
100 | 84 | 45 | 157 | 62 | 77* | ||
76 | 37 | 210 | 92 | ||||
125 | 70 | 22 | 393 | 188 | 178* | ||
68 | 23 | 342 | 169 | ||||
150 | 30 | 4 | 445 | 494 | 597* | ||
26 | 3 | 535 | 699 | ||||
175 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 45 | 20 | 218 | 161 | 176* |
42 | 22 | 240 | 191 | ||||
Methyl Methane Sulfonate | 250 | 62 | 66 | 307 | 166 | 154* | |
69 | 59 | 293 | 142 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 83 | 97 | 52 | 21 | 27 |
80 | 96 | 101 | 42 | ||||
78 | 94 | 65 | 28 | ||||
85 | 113 | 46 | 18 | ||||
Test Chemical | Chlorobenzene | 40 | 76 | 73 | 46 | 20 | 19 |
78 | 95 | 41 | 18 | ||||
70 | 83 | 69 | 60 | 24 | 27 | ||
73 | 67 | 67 | 31 | ||||
100 | 86 | 35 | 95 | 37 | 37 | ||
72 | 44 | 79 | 37 | ||||
130 | 67 | 19 | 88 | 44 | 42 | ||
56 | 14 | 68 | 40 | ||||
160 | 16 | 1 | 34 | 70 | 75* | ||
28 | 3 | 67 | 79 | ||||
190 | |||||||
220 | |||||||
Positive Control | Methyl Methane Sulfonate | 20 | 29 | 16 | 167 | 189 | 165* |
37 | 25 | 159 | 142 | ||||
Methyl Methane Sulfonate | 250 | 65 | 71 | 399 | 204 | 223* | |
74 | 64 | 542 | 243 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 90 | 101 | 166 | 61 | 54 |
60 | 98 | 95 | 53 | ||||
78 | 99 | 128 | 55 | ||||
62 | 102 | 86 | 47 | ||||
Test Chemical | Chlorobenzene | 135 | 45 | 29 | 86 | 64 | 64 |
44 | 27 | 83 | 64 | ||||
150 | 37 | 22 | 81 | 72 | 71 | ||
37 | 20 | 79 | 71 | ||||
165 | 47 | 16 | 92 | 66 | 58 | ||
53 | 22 | 80 | 50 | ||||
180 | 39 | 7 | 70 | 60 | 83 | ||
51 | 9 | 162 | 106 | ||||
195 | 14 | 1 | 95 | 226 | 197* | ||
22 | 2 | 110 | 168 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 25 | 19 | 156 | 212 | 195* |
25 | 18 | 135 | 178 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 61 | 103 | 84 | 46 | 49 |
67 | 95 | 87 | 43 | ||||
52 | 102 | 72 | 46 | ||||
55 | 101 | 101 | 61 | ||||
Test Chemical | Chlorobenzene | 70 | 49 | 22 | 181 | 124 | 112* |
54 | 29 | 160 | 99 | ||||
100 | 75 | 28 | 256 | 114 | 118* | ||
66 | 25 | 241 | 122 | ||||
130 | 57 | 26 | 153 | 90 | 103* | ||
62 | 31 | 218 | 117 | ||||
160 | 52 | 21 | 179 | 116 | 107* | ||
55 | 21 | 162 | 99 | ||||
190 | 35 | 15 | 100 | 95 | 114* | ||
30 | 11 | 121 | 134 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 46 | 30 | 500 | 364 | 403* |
36 | 35 | 474 | 443 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 70 | 109 | 113 | 54 | 64 |
63 | 83 | 138 | 73 | ||||
72 | 98 | 84 | 39 | ||||
66 | 110 | 176 | 89 | ||||
Test Chemical | Chlorobenzene | 70 | 61 | 29 | 253 | 138 | 117* |
71 | 36 | 205 | 96 | ||||
100 | 50 | 22 | 148 | 98 | 104* | ||
54 | 35 | 180 | 110 | ||||
130 | 44 | 21 | 155 | 117 | 102* | ||
67 | 43 | 174 | 86 | ||||
160 | 41 | 14 | 219 | 179 | 161* | ||
45 | 16 | 193 | 143 | ||||
190 | 22 | 5 | 93 | 143 | 172* | ||
23 | 4 | 138 | 200 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 31 | 20 | 572 | 622 | 517* |
26 | 17 | 327 | 411 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination