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Study Information
Study Attribute Value
CEBS Accession Number: 002-01863-0012-0000-3
Chemical Name: Chlorobenzene
CASRN: 108-90-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 569047_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/27/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.87 ± 0.160
Test Chemical Chlorobenzene 
250         
 4 4.96 ± 0.397
  
500         
 4 4.43 ± 0.270
  
1000         
 4 6.06 ± 0.627
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.03 ± 0.784


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/02/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.40 ± 1.084
Test Chemical Chlorobenzene 
87.5       
 4 8.17 ± 0.961
  
175         
 4 7.41 ± 1.571
  
350         
 4 5.70 ± 0.809
Positive Control Dimethylbenzanthracene 
2.5       
 4 13.69 ± 0.715


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/10/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.99 ± 0.394
Test Chemical Chlorobenzene 
1000         
 4 5.08 ± 0.356
  
1250         
 4 5.75 ± 0.324
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.03 ± 0.335


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed