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Study Information
Study Attribute Value
CEBS Accession Number: 002-01863-0013-0000-4
Chemical Name: Chlorobenzene
CASRN: 108-90-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 569047_CA
Study Result: Positive (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/08/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.4656
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 13.50 ± 1.50 0.0000
Test Chemical Chlorobenzene 
312.5       
 8 3.25 ± 0.92 0.0137
  
625         
 8 1.75 ± 0.59 0.1812
  
1250         
 7 1.71 ± 0.68 0.1974
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/26/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0009
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 7 17.14 ± 2.79 0.0000
Test Chemical Chlorobenzene 
250         
 6 2.67 ± 1.12 0.1376
  
500         
 8 2.25 ± 0.96 0.2171
  
1000         
 8 5.25 ± 2.33 0.0017
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.82 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed