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Study Information
Study Attribute Value
CEBS Accession Number: 002-01864-0001-0000-2
Chemical Name: Chlorobenzilate
CASRN: 510-15-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 486951_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1   
No Activation  2  Negative 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9   
Induced Rat Liver S9  3_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/09/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 463 0.446 9.26 25.8 0.000
Test Chemical Chlorobenzilate 
5         
 50 1032 434 0.421 8.68 25.8 -5.809 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 526 700 1.331 28.00 25.8 198.064
Trend: -0.896        
Probability: 0.815        

Trial #: 2    Activation: No Activation    Date: 07/14/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 489 0.466 9.78 25.8 0.000
Test Chemical Chlorobenzilate 
10         
 50 1048 452 0.431 9.04 25.8 -7.390 
12.6       
 50 1055 485 0.460 9.70 25.8 -1.288 
15         
 50 1034 472 0.456 9.44 25.8 -1.983
Positive Control Mitomycin-C 
 0.005     
 25 526 824 1.567 32.96 25.8 236.374
Trend: 0.025        
Probability: 0.490        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/09/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 502 0.480 10.04 25.8 0.000
Test Chemical Chlorobenzilate 
5         
 50 1053 428 0.406 8.56 25.8 -15.389 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 523 1074 2.054 42.96 25.8 327.479
Trend: -2.543        
Probability: 0.995        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/14/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 450 0.431 9.00 25.8 0.000
Test Chemical Chlorobenzilate 
15         
 50 1047 459 0.438 9.18 25.8 1.805
Positive Control Cyclophosphamide 
1.5       
 25 526 880 1.673 35.20 25.8 288.509
Trend: 0.000        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 07/21/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 467 0.447 9.34 25.8 0.000
Test Chemical Chlorobenzilate 
10         
 50 1041 475 0.456 9.50 25.8 2.104 
20         
 50 1045 468 0.448 9.36 25.8 0.214 
30         
 50 1050 544 0.518 10.88 25.8 15.934 
40         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 525 914 1.741 36.56 25.8 289.571
Trend: 2.032        
Probability: 0.021