Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01864-0002-0000-3 |
Chemical Name: | Chlorobenzilate |
CASRN: | 510-15-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 486951_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 7 | 0.070 | 7.0 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 4.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Chlorobenzilate | 10 | 100 | 7 | 0.070 | 4.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 2.0 | 0 | 0.000 | 0.0 |
20 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | ||
30 | 100 | 9 | 0.090 | 8.0 | 4 | 0.040 | 4.0 | 4 | 0.040 | 2.0 | 1 | 0.010 | 1.0 | ||
40 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.5 | 50 | 15 | 0.300 | 20.0 | 10 | 0.200 | 14.0 | 5 | 0.100 | 8.0 | 0 | 0.000 | 0.0 |
Trend: | 1.164 | -0.211 | 1.082 | ||||||||||||
Probability: | 0.122 | 0.584 | 0.140 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Chlorobenzilate | 1 | 100 | 7 | 0.070 | 7.0 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
5 | 100 | 9 | 0.090 | 8.0 | 5 | 0.050 | 5.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | ||
10 | 100 | 9 | 0.090 | 3.0 | 3 | 0.030 | 2.0 | 5 | 0.050 | 1.0 | 1 | 0.010 | 1.0 | ||
20 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
30 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 25 | 50 | 8 | 0.160 | 16.0 | 3 | 0.060 | 6.0 | 5 | 0.100 | 10.0 | 0 | 0.000 | 0.0 |
Trend: | -0.692 | -0.433 | -0.585 | ||||||||||||
Probability: | 0.755 | 0.668 | 0.721 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 |
Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Chlorobenzilate | 10 | 50 | 1 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.020 | 2.0 |
15 | 100 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | ||
20 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
25 | 20 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
30 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 62.5 | 50 | 18 | 0.360 | 26.0 | 15 | 0.300 | 22.0 | 3 | 0.060 | 4.0 | 0 | 0.000 | 0.0 |
Trend: | 0.096 | -0.195 | 0.781 | ||||||||||||
Probability: | 0.462 | 0.577 | 0.217 |