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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0001-0000-3
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 096876_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/05/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 395 0.377 7.90 26.1 0.000
Test Chemical Chlorodibromomethane 
50         
 50 1046 410 0.392 8.20 26.1 3.897 
166.7       
 50 1041 436 0.419 8.72 31.8 11.016 
500.2       
 50 1044 554 0.531 11.08 31.8 40.656 
1700         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 519 0.495 10.38 26.1 31.142
Mitomycin-C 
 0.01      
 5 104 223 2.144 44.60 26.1 468.357
Trend: 5.326        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/31/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 523 222 0.424 8.88 25.8 0.000
Test Chemical Chlorodibromomethane 
251.4       
 25 524 229 0.437 9.16 25.8 2.956 
502.7       
 25 524 270 0.515 10.80 31.5 21.390 
750.3       
 25 522 306 0.586 12.24 31.5 38.102 
1000.4       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 526 310 0.589 12.40 25.8 38.843
Mitomycin-C 
 0.01      
 5 105 290 2.762 58.00 25.8 550.665
Trend: 4.119        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/05/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 448 0.429 8.96 26.1 0.000
Test Chemical Chlorodibromomethane 
166.7       
 50 1046 443 0.424 8.86 26.1 -1.305 
500.2       
 50 1047 455 0.435 9.10 26.1 1.271 
1667         
 50 1045 436 0.417 8.72 26.1 -2.772 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1046 572 0.547 11.44 26.1 27.434
Cyclophosphamide 
2         
 5 105 123 1.171 24.60 26.1 172.985
Trend: -0.282        
Probability: 0.611