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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0002-0000-4
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 096876_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Questionable 

Trial #:1   Activation: No Activation    Date: 12/21/1987    Harvest Time: 20.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chlorodibromomethane 
1200         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
1500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1800         
 100 2 0.020 1.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 6 0.060 6.0 4 0.040 4.0 2 0.020 2.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 11 0.440 24.0 4 0.160 16.0 7 0.280 16.0 0 0.000 0.0
Trend: 0.218 1.307 0.218  
Probability: 0.414 0.096 0.414  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/07/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 10 0.050 3.5 5 0.025 2.5 5 0.025 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 8 0.040 4.0 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Chlorodibromomethane 
745.3       
 200 9 0.045 4.5 4 0.020 2.0 5 0.025 2.5 0 0.000 0.0 
1490.5       
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0 
3011.2       
 200 7 0.035 3.0 4 0.020 1.5 3 0.015 1.5 0 0.000 0.0 
3501.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 27 0.135 11.5 4 0.020 2.0 23 0.115 10.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 13 0.520 36.0 2 0.080 8.0 11 0.440 28.0 0 0.000 0.0
Trend: -0.697 -0.622 -0.373  
Probability: 0.757 0.733 0.645  


Trial #:2   Activation: No Activation    Date: 04/29/1987    Harvest Time: 20.3 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 2 0.010 1.0 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Chlorodibromomethane 
900.4       
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
1200.5       
 200 12 0.060 6.0 4 0.020 2.0 8 0.040 4.0 0 0.000 0.0 
1500.6       
 200 8 0.040 3.5 2 0.010 1.0 6 0.030 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 54 0.270 18.5 11 0.055 5.0 43 0.215 16.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 9 0.360 32.0 2 0.080 8.0 7 0.280 28.0 0 0.000 0.0
Trend: 2.057 0.509 1.776  
Probability: 0.020 0.305 0.038