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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0003-0000-5
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 261721_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/18/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 437 0.417 8.74 26.5 0.000
Test Chemical Chlorodibromomethane 
24.7       
 50 1045 437 0.418 8.74 26.5 0.287 
74         
 50 1047 492 0.470 9.84 26.5 12.693 
247         
 50 1050 479 0.456 9.58 26.5 9.402
Positive Control Mitomycin-C 
 0.0015    
 50 1049 671 0.640 13.42 26.5 53.401
Mitomycin-C 
 0.01      
 10 210 318 1.514 31.80 26.5 263.151
Trend: 1.825        
Probability: 0.034        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/18/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 494 0.472 9.88 26.0 0.000
Test Chemical Chlorodibromomethane 
74         
 50 1046 556 0.532 11.12 26.0 12.551 
247         
 50 1053 592 0.562 11.84 26.0 19.041 
740         
 50 1042 599 0.575 11.98 26.0 21.721
Positive Control Cyclophosphamide 
 0.4       
 50 1043 983 0.942 19.66 26.0 99.560
Cyclophosphamide 
2.5       
 10 210 476 2.267 47.60 26.0 379.946
Trend: 3.354        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/23/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 379 0.362 7.58 26.0 0.000
Test Chemical Chlorodibromomethane 
790         
 50 1042 502 0.482 10.04 26.0 33.217 
890         
 50 1037 427 0.412 8.54 26.0 13.860 
990         
 50 1049 468 0.446 9.36 30.0 23.365
Positive Control Cyclophosphamide 
 0.4       
 50 1038 673 0.648 13.46 26.0 79.283
Cyclophosphamide 
2.5       
 10 210 348 1.657 34.80 26.0 358.228
Trend: 2.015        
Probability: 0.022