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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0004-0000-6
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 261721_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 07/16/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorodibromomethane 
124         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
398         
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 1.0 0 0.000 0.0 
1240         
 100 7 0.070 6.0 0 0.000 0.0 7 0.070 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 36 0.360 26.0 11 0.110 10.0 25 0.250 19.0 0 0.000 0.0
Mitomycin-C 
5         
 50 24 0.480 36.0 10 0.200 18.0 14 0.280 22.0 0 0.000 0.0
Trend: 1.997 0.000 1.997  
Probability: 0.023 0.000 0.023  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/06/1985    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorodibromomethane 
1020         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1520         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
2540         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 10 16 1.600 80.0 8 0.800 60.0 8 0.800 40.0 0 0.000 0.0
Trend: 1.236 -0.425 1.431  
Probability: 0.108 0.664 0.076  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/16/1985    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 1.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorodibromomethane 
248         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0 
795         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
1240         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
2480         
 100 8 0.080 8.0 0 0.000 0.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 59 1.180 48.0 12 0.240 22.0 17 0.340 26.0 30 0.600 3.0
Trend: 2.265 -0.565 2.161  
Probability: 0.012 0.714 0.015