Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01865-0014-0000-7
Chemical Name:	Chlorodibromomethane
CASRN:	124-48-1
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	988921
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	79	146	128	54	47
			58	87	88	50
			61	83	81	45
			61	84	73	40
Test Chemical	Chlorodibromomethane	12.5	77	83	122	53	47
			78	86	96	41	47
		25	79	91	89	37	46
			64	72	104	54	46
		50	66	80	107	54	49
			72	73	94	43	49
		100	64	57	77	40	48
			68	57	112	55	48
		200	62	16	193	105	116*
			58	18	223	128	116*
Positive Control	Methyl Methane Sulfonate	15	22	18	198	296	302*
			25	20	235	309	302*
	Methyl Methane Sulfonate	250	57	63	413	240	240*
			45	58	324	240	240*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	97	105	128	44	40
			95	97	80	28
			87	91	124	47
			89	107	103	39
Test Chemical	Chlorodibromomethane	50	76	91	122	54	55
			71	84	120	56	55
		100	69	38	245	119	129*
			80	49	330	138	129*
		150	61	15	448	246	241*
			68	17	476	235	241*
		200	44	6	511	387	385*
			45	5	511	383	385*
		250

		300

Positive Control	Methyl Methane Sulfonate	15	34	21	195	194	215*
			34	26	242	236	215*
	Methyl Methane Sulfonate	250	72	66	418	193	202*
			53	61	337	211	202*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination