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Study Information
Study Attribute Value
CEBS Accession Number: 002-01865-0016-0000-9
Chemical Name: Chlorodibromomethane
CASRN: 124-48-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 687058_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/31/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.5379
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 12.50 ± 2.38 0.0000
Test Chemical Chlorodibromomethane 
125         
 8 3.50 ± 1.80 0.0035
  
250         
 8 1.50 ± 0.50 0.1573
  
500         
 8 1.50 ± 0.63 0.1573
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/31/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 24.25 ± 4.32 0.0000
Test Chemical Chlorodibromomethane 
125         
 8 6.25 ± 1.67 0.0041
  
250         
 8 4.50 ± 0.91 0.0491
  
500         
 8 14.75 ± 4.70 0.0000
Vehicle Control No Stressor 
 0         
 7 2.29 ± 0.81 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/14/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0988
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 23.25 ± 3.68 0.0000
Test Chemical Chlorodibromomethane 
250         
 8 5.25 ± 1.46 0.2000
  
375         
 8 6.00 ± 0.93 0.0972
  
500         
 8 5.75 ± 1.39 0.1252
Vehicle Control No Stressor 
 0         
 8 4.00 ± 1.13 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/17/90 35 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 35 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 34.29 ± 4.03 0.0000
Test Chemical Chlorodibromomethane 
250         
 8 4.75 ± 1.36 0.0084
  
375         
 8 6.25 ± 0.70 0.0006
  
500         
 8 12.25 ± 1.87 0.0000
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed