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Study Information
Study Attribute Value
CEBS Accession Number: 002-01867-0012-0000-7
Chemical Name: Chloroform
CASRN: 67-66-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 142011_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/30/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.48 ± 0.302
Test Chemical Chloroform 
50         
 4 5.01 ± 0.125
  
100         
 4 5.38 ± 0.114
  
200         
 4 8.66 ± 1.742
Positive Control Dimethylbenzanthracene 
2.5       
 4 10.37 ± 2.301


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/05/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.90 ± 0.548
Test Chemical Chloroform 
200         
 4 6.40 ± 0.486
  
400         
 4 7.74 ± 0.670
  
800         
 4 7.26 ± 0.549
Positive Control Dimethylbenzanthracene 
200         
 4 13.03 ± 0.464


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/25/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.86 ± 0.457
Test Chemical Chloroform 
100         
 4 6.43 ± 0.593
  
200         
 4 5.25 ± 0.398
  
400         
 4 5.40 ± 0.493
Positive Control Dimethylbenzanthracene 
2.5       
 4 13.18 ± 0.379


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed