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Study Information
Study Attribute Value
CEBS Accession Number: 002-01867-0013-0000-8
Chemical Name: Chloroform
CASRN: 67-66-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 142011_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/20/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.5000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 18.00 ± 2.98 0.0000
Test Chemical Chloroform 
200         
 8 2.00 ± 1.00 0.1223
  
400         
 8 1.75 ± 0.70 0.1812
  
800         
 8 1.25 ± 0.53 0.3687
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/16/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7807
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.50 ± 1.35 0.0000
Test Chemical Chloroform 
800         
 8 0.50 ± 0.33 0.9224
  
1000         
 8 1.25 ± 0.37 0.6193
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.73 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed