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Study Information
Study Attribute Value
CEBS Accession Number: 002-01873-0002-0000-3
Chemical Name: Chlorothalonil
CASRN: 1897-45-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 739007_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 10/01/1982    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorothalonil 
 0.5       
 100 49 0.490 19.0 16 0.160 12.0 33 0.330 15.0 0 0.000 0.0 
 0.6       
 100 31 0.310 8.0 6 0.060 5.0 15 0.150 9.0 10 0.100 1.0 
 0.7       
 100 40 0.400 14.0 17 0.170 9.0 23 0.230 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 50 20 0.400 18.0 11 0.220 14.0 9 0.180 12.0 0 0.000 0.0
Trend: 1.994 1.776 1.437  
Probability: 0.023 0.038 0.075  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/01/1982    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Chlorothalonil 
2         
 100 22 0.220 9.0 7 0.070 6.0 14 0.140 6.0 1 0.010 1.0 
2.5       
 100 58 0.580 26.0 28 0.280 18.0 29 0.290 17.0 1 0.010 1.0 
3         
 100 73 0.730 26.0 27 0.270 17.0 36 0.360 18.0 10 0.100 1.0
Positive Control: Cyclophosphamide 
10         
 50 9 0.180 18.0 9 0.180 18.0 0 0.000 0.0 0 0.000 0.0
Trend: 5.979 4.709 4.840  
Probability: 0.000 0.000 0.000