Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01873-0002-0000-3 |
Chemical Name: | Chlorothalonil |
CASRN: | 1897-45-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 739007_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 |
Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Chlorothalonil | 0.5 | 100 | 49 | 0.490 | 19.0 | 16 | 0.160 | 12.0 | 33 | 0.330 | 15.0 | 0 | 0.000 | 0.0 |
0.6 | 100 | 31 | 0.310 | 8.0 | 6 | 0.060 | 5.0 | 15 | 0.150 | 9.0 | 10 | 0.100 | 1.0 | ||
0.7 | 100 | 40 | 0.400 | 14.0 | 17 | 0.170 | 9.0 | 23 | 0.230 | 9.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.065 | 50 | 20 | 0.400 | 18.0 | 11 | 0.220 | 14.0 | 9 | 0.180 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 1.994 | 1.776 | 1.437 | ||||||||||||
Probability: | 0.023 | 0.038 | 0.075 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 4 | 0.040 | 3.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Chlorothalonil | 2 | 100 | 22 | 0.220 | 9.0 | 7 | 0.070 | 6.0 | 14 | 0.140 | 6.0 | 1 | 0.010 | 1.0 |
2.5 | 100 | 58 | 0.580 | 26.0 | 28 | 0.280 | 18.0 | 29 | 0.290 | 17.0 | 1 | 0.010 | 1.0 | ||
3 | 100 | 73 | 0.730 | 26.0 | 27 | 0.270 | 17.0 | 36 | 0.360 | 18.0 | 10 | 0.100 | 1.0 | ||
Positive Control: | Cyclophosphamide | 10 | 50 | 9 | 0.180 | 18.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Trend: | 5.979 | 4.709 | 4.840 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |