Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01877-0001-0000-6 |
Chemical Name: | Chlorpheniramine maleate |
CASRN: | 113-92-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 982295_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
No Activation | 2 | Weakly Positive |
No Activation | 3 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Induced Rat Liver S9 | 2_S9 | Test Failure |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1030 | 337 | 0.327 | 6.74 | 26.5 | -17.313 |
Dimethyl Sulfoxide | 0 | 50 | 1021 | 404 | 0.396 | 8.08 | 26.5 | 0.000 | |
Test Chemical | Chlorpheniramine maleate | 0.5 | 50 | 1034 | 408 | 0.395 | 8.16 | 26.5 | -0.280 |
1.6 | 50 | 1047 | 412 | 0.394 | 8.24 | 26.5 | -0.552 | ||
5 | 50 | 1043 | 419 | 0.402 | 8.38 | 26.5 | 1.525 | ||
16 | 50 | 1039 | 449 | 0.432 | 8.98 | 26.5 | 9.213 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
160 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1049 | 1394 | 1.329 | 27.88 | 26.5 | 235.839 |
Mitomycin-C | 0.01 | 10 | 210 | 752 | 3.581 | 75.20 | 26.5 | 804.988 | |
Trend: | 1.284 | ||||||||
Probability: | 0.100 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1044 | 394 | 0.377 | 7.88 | 26.0 | -7.529 |
Dimethyl Sulfoxide | 0 | 50 | 1034 | 422 | 0.408 | 8.44 | 26.0 | 0.000 | |
Test Chemical | Chlorpheniramine maleate | 16 | 50 | 1036 | 444 | 0.429 | 8.88 | 26.0 | 5.010 |
25 | 50 | 1033 | 433 | 0.419 | 8.66 | 26.0 | 2.706 | ||
50 | 50 | 1035 | 424 | 0.410 | 8.48 | 26.0 | 0.377 | ||
100 | 50 | 1040 | 511 | 0.491 | 10.22 | 31.0 | 20.391 | ||
200 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1039 | 1303 | 1.254 | 26.06 | 26.0 | 207.282 |
Mitomycin-C | 0.01 | 10 | 204 | 510 | 2.500 | 51.00 | 26.0 | 512.559 | |
Trend: | 2.410 | ||||||||
Probability: | 0.008 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1047 | 419 | 0.400 | 8.38 | 26.0 | 0.000 |
Test Chemical | Chlorpheniramine maleate | 75 | 50 | 1050 | 496 | 0.472 | 9.92 | 31.0 | 18.039 |
125 | 50 | 1049 | 546 | 0.520 | 10.92 | 31.0 | 30.062 | ||
150 | 50 | 1048 | 519 | 0.495 | 10.38 | 31.0 | 23.748 | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1050 | 561 | 0.534 | 11.22 | 26.0 | 33.508 |
Mitomycin-C | 0.005 | 10 | 210 | 250 | 1.190 | 25.00 | 26.0 | 197.477 | |
Trend: | 3.759 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1040 | 457 | 0.439 | 9.14 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1047 | 469 | 0.448 | 9.38 | 26.0 | 1.940 | |
Test Chemical | Chlorpheniramine maleate | 5 | 50 | 1046 | 457 | 0.437 | 9.14 | 26.0 | -0.574 |
16 | 50 | 1038 | 444 | 0.428 | 8.88 | 26.0 | -2.657 | ||
50 | 50 | 1046 | 454 | 0.434 | 9.08 | 26.0 | -1.226 | ||
160 | 50 | 1047 | 443 | 0.423 | 8.86 | 26.0 | -3.712 | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.3 | 50 | 1035 | 567 | 0.548 | 11.34 | 26.0 | 24.669 |
Cyclophosphamide | 2 | 10 | 208 | 247 | 1.188 | 24.70 | 26.0 | 170.241 | |
Trend: | -0.553 | ||||||||
Probability: | 0.710 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 443 | 0.424 | 8.86 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1040 | 449 | 0.432 | 8.98 | 26.0 | 1.939 | |
Test Chemical | Chlorpheniramine maleate | 200 | 50 | 1045 | 407 | 0.389 | 8.14 | 26.0 | -8.038 |
300 | 50 | 1042 | 444 | 0.426 | 8.88 | 26.0 | 0.610 | ||
400 | 50 | 1049 | 465 | 0.443 | 9.30 | 26.0 | 4.666 | ||
500 | 50 | 1043 | 491 | 0.471 | 9.82 | 26.0 | 11.154 | ||
Positive Control | Cyclophosphamide | 0.3 | 50 | 1047 | 527 | 0.503 | 10.54 | 26.0 | 18.848 |
Cyclophosphamide | 2 | 10 | 211 | 256 | 1.213 | 25.60 | 26.0 | 186.474 | |
Trend: | 2.266 | ||||||||
Probability: | 0.012 |