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Study Information
Study Attribute Value
CEBS Accession Number: 002-01877-0002-0000-7
Chemical Name: Chlorpheniramine maleate
CASRN: 113-92-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 982295_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 
No Activation  3  Negative 

Trial #:1   Activation: No Activation    Date: 05/04/1984    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorpheniramine maleate 
100         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
200         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
300         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
400         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 25 0.250 23.0 14 0.140 13.0 11 0.110 11.0 0 0.000 0.0
Mitomycin-C 
1         
 50 27 0.540 36.0 13 0.260 24.0 13 0.260 18.0 1 0.020 1.0
Trend: 0.281 -1.189 1.187  
Probability: 0.389 0.883 0.118  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/09/1984    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Chlorpheniramine maleate 
16         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
160         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 19 0.190 18.0 3 0.030 3.0 16 0.160 16.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 15 0.150 13.0 4 0.040 4.0 11 0.110 9.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 38 0.760 54.0 16 0.320 28.0 21 0.420 32.0 1 0.020 1.0
Trend: 3.846 0.803 4.160  
Probability: 0.000 0.211 0.000  


Trial #:2   Activation: No Activation    Date: 02/10/1984    Harvest Time: 11.7 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Chlorpheniramine maleate 
5         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
16         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
50         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
160         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 28 0.280 23.0 13 0.130 13.0 15 0.150 11.0 0 0.000 0.0
Mitomycin-C 
1         
 50 21 0.420 40.0 6 0.120 12.0 15 0.300 28.0 0 0.000 0.0
Trend: -0.904 -0.814 -0.542  
Probability: 0.817 0.792 0.706  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/28/1984    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 3 0.030 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 2.0 0 0.000 0.0
Test Chemical: Chlorpheniramine maleate 
300         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
400         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 8 0.080 6.0 0 0.000 0.0 8 0.080 6.0 0 0.000 0.0 
750         
 26 6 0.231 19.0 1 0.038 4.0 5 0.192 19.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 56 0.560 42.0 32 0.320 27.0 24 0.240 23.0 0 0.000 0.0
Cyclophosphamide 
50         
 100 87 0.870 51.0 32 0.320 26.0 55 0.550 39.0 0 0.000 0.0
Trend: 2.864 0.343 3.470  
Probability: 0.002 0.366 0.000  


Trial #:3   Activation: No Activation    Date: 03/29/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Chlorpheniramine maleate 
100         
 100 8 0.080 5.0 3 0.030 2.0 5 0.050 4.0 0 0.000 0.0 
200         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
300         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
400         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 45 0.450 30.0 18 0.180 16.0 27 0.270 17.0 0 0.000 0.0
Mitomycin-C 
1         
 50 28 0.560 48.0 8 0.160 16.0 20 0.400 38.0 0 0.000 0.0
Trend: 0.645 1.217 -0.376  
Probability: 0.259 0.112 0.647