| Study Attribute | Value | 
|---|---|
| CEBS Accession Number: | 002-01877-0010-0000-6 | 
| Chemical Name: | Chlorpheniramine maleate | 
| CASRN: | 113-92-8 | 
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity | 
| NTP Study ID: | 501757 | 
| Study Result: | Negative | 
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 93 | 97 | 129 | 46 | 45 | 
| 81 | 100 | 132 | 54 | ||||
| 94 | 104 | 100 | 36 | ||||
| 99 | 99 | 129 | 44 | ||||
| Test Chemical | Chlorpheniramine maleate | 10 | 72 | 79 | 101 | 47 | 40 | 
| 96 | 88 | 96 | 33 | ||||
| 50 | 61 | 51 | 130 | 72 | 59 | ||
| 66 | 33 | 94 | 47 | ||||
| 90 | 79r | 13 | 152 | 64 | |||
| 72 | 37 | 122 | 56 | ||||
| 130 | 85 | 20 | 169 | 66 | 62 | ||
| 95 | 18 | 166 | 58 | ||||
| 170 | 75 | 8 | 145 | 64 | 63 | ||
| 58 | 9 | 109 | 62 | ||||
| 210 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 43 | 11 | 462 | 360 | 360* | 
| 35 | 30 | 383 | 361 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 99 | 87 | 125 | 42 | 36 | 
| 95 | 119 | 89 | 31 | ||||
| 86 | 102 | 77 | 30 | ||||
| 89 | 92 | 105 | 39 | ||||
| Test Chemical | Chlorpheniramine maleate | 75 | 61 | 24 | 93 | 51 | 55 | 
| 68 | 31 | 120 | 59 | ||||
| 150 | 99 | 22 | 110 | 37 | 41 | ||
| 76 | 29 | 103 | 45 | ||||
| 175 | 65 | 9 | 86 | 44 | 42 | ||
| 84 | 22 | 103 | 41 | ||||
| 200 | 84 | 14 | 61 | 24 | 27 | ||
| 47 | 6 | 43 | 31 | ||||
| 225 | 84 | 10 | 61 | 24 | 27 | ||
| 45 | 9 | 40 | 30 | ||||
| 250 | |||||||
| 275 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 77 | 74 | 87 | 38 | 34 | 
| 83 | 79 | 75 | 30 | ||||
| Methyl Methane Sulfonate | 250 | 67 | 80 | 398 | 199 | 186* | |
| 67 | 85 | 350 | 173 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 72 | 104 | 108 | 50 | 55 | 
| 62 | 94 | 109 | 59 | ||||
| 64 | 106 | 118 | 62 | ||||
| 77 | 97 | 118 | 51 | ||||
| Test Chemical | Chlorpheniramine maleate | 90 | 99 | 105 | 158 | 53 | 48 | 
| 101 | 123 | 131 | 43 | ||||
| 120 | 90 | 103 | 133 | 50 | 49 | ||
| 82 | 59 | 118 | 48 | ||||
| 150 | 83 | 51 | 148 | 60 | 59 | ||
| 96 | 86 | 166 | 57 | ||||
| 180 | 76 | 81 | 82 | 36 | 44 | ||
| 80 | 85 | 125 | 52 | ||||
| 210 | 77 | 25 | 158 | 68 | 72 | ||
| 60 | 28 | 134 | 75 | ||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 69 | 37 | 723 | 348 | 347* | 
| 59 | 29 | 616 | 346 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 74 | 121 | 121 | 55 | 58 | 
| 81 | 81 | 128 | 52 | ||||
| 81 | 105 | 141 | 58 | ||||
| 85 | 93 | 174 | 68 | ||||
| Test Chemical | Chlorpheniramine maleate | 110 | 85 | 72 | 112 | 44 | 49 | 
| 82 | 92 | 132 | 53 | ||||
| 140 | 76 | 69 | 125 | 55 | 50 | ||
| 77 | 78 | 102 | 44 | ||||
| 170 | 79 | 48 | 162 | 68 | 63 | ||
| 94 | 58 | 162 | 58 | ||||
| 200 | 102 | 45 | 119 | 39 | 50 | ||
| 62 | 45 | 113 | 61 | ||||
| 230 | 75 | 29 | 114 | 51 | 48 | ||
| 94 | 35 | 130 | 46 | ||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 52 | 14 | 722 | 463 | 504* | 
| 43 | 16 | 702 | 544 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 58 | 89 | 135 | 78 | 82 | 
| 77 | 106 | 207 | 89 | ||||
| 76 | 110 | 192 | 84 | ||||
| 72 | 95 | 163 | 75 | ||||
| Test Chemical | Chlorpheniramine maleate | 200 | 44 | 35 | 458 | 350 | 326* | 
| 48 | 34 | 437 | 302 | ||||
| 225 | 34 | 22 | 329 | 323 | 268* | ||
| 42 | 29 | 270 | 213 | ||||
| 250 | 30 | 24 | 491 | 543 | 471* | ||
| 45 | 34 | 536 | 400 | ||||
| 275 | 31 | 16 | 770 | 819 | 715* | ||
| 35 | 18 | 644 | 610 | ||||
| 300 | 33 | 13 | 783 | 783 | 633* | ||
| 32 | 16 | 456 | 483 | ||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 38 | 27 | 415 | 366 | 408* | 
| 37 | 25 | 498 | 451 | ||||
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination
 
                        