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Study Information
Study Attribute Value
CEBS Accession Number: 002-01878-0001-0000-7
Chemical Name: Chlorpromazine hydrochloride
CASRN: 69-09-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333439_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/16/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 474 0.452 9.48 26.0 0.000
Test Chemical Chlorpromazine hydrochloride 
 0.05      
 50 1041 430 0.413 8.60 26.0 -8.586 
 0.16      
 50 1032 452 0.438 9.04 26.0 -3.071 
 0.5       
 50 1035 423 0.409 8.46 26.0 -9.552 
1.6       
 50 1037 450 0.434 9.00 26.0 -3.965
Positive Control Mitomycin-C 
 0.005     
 25 525 616 1.173 24.64 26.0 159.668
Trend: -0.627        
Probability: 0.735        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/16/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 414 0.396 8.28 26.0 0.000
Test Chemical Chlorpromazine hydrochloride 
1.6       
 50 1048 444 0.424 8.88 26.0 7.042 
5         
 50 1046 460 0.440 9.20 26.0 11.111 
16         
 50 1034 466 0.451 9.32 26.0 13.867
Positive Control Cyclophosphamide 
1.5       
 50 1046 1130 1.080 22.60 26.0 172.947
Trend: 1.995        
Probability: 0.023