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Study Information
Study Attribute Value
CEBS Accession Number: 002-01878-0002-0000-8
Chemical Name: Chlorpromazine hydrochloride
CASRN: 69-09-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333439_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/16/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0
Test Chemical: Chlorpromazine hydrochloride 
 0.5       
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
1.6       
 100 12 0.120 10.0 1 0.010 1.0 11 0.110 9.0 0 0.000 0.0 
5         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 32 0.640 38.0 3 0.060 6.0 29 0.580 36.0 0 0.000 0.0
Trend: 1.163 1.468 0.509  
Probability: 0.122 0.071 0.306  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/16/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Chlorpromazine hydrochloride 
1.6       
 100 7 0.070 5.0 0 0.000 0.0 7 0.070 5.0 0 0.000 0.0 
5         
 100 14 0.140 11.0 2 0.020 2.0 12 0.120 9.0 0 0.000 0.0 
16         
 100 11 0.110 10.0 2 0.020 2.0 9 0.090 9.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 29 0.290 24.0 8 0.080 8.0 21 0.210 18.0 0 0.000 0.0
Trend: 2.033 1.004 1.993  
Probability: 0.021 0.158 0.023