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Study Information
Study Attribute Value
CEBS Accession Number: 002-01879-0001-0000-8
Chemical Name: Chlorpropamide
CASRN: 94-20-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 952992_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/29/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 376 0.359 7.52 27.0 0.000
Test Chemical Chlorpropamide 
26.6       
 50 1050 370 0.352 7.40 27.0 -1.877 
88.5       
 50 1046 390 0.373 7.80 27.0 3.823 
266         
 50 1048 434 0.414 8.68 27.0 15.315
Positive Control Mitomycin-C 
 0.0015    
 50 1044 576 0.552 11.52 27.0 53.632
Mitomycin-C 
 0.01      
 10 207 312 1.507 31.20 27.0 319.704
Trend: 2.182        
Probability: 0.015        

Trial #: 2    Activation: No Activation    Date: 02/20/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 400 0.382 8.00 30.5 0.000
Test Chemical Chlorpropamide 
166         
 50 1048 511 0.488 10.22 30.0 27.506 
332         
 50 1046 533 0.510 10.66 30.0 33.250 
498         
 50 1049 621 0.592 12.42 30.0 54.806
Positive Control Mitomycin-C 
 0.0015    
 50 1047 601 0.574 12.02 30.5 50.106
Mitomycin-C 
 0.01      
 10 209 348 1.665 34.80 30.5 335.416
Trend: 6.593        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 03/05/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 385 0.368 7.70 26.5 0.000
Test Chemical Chlorpropamide 
370         
 50 1045 638 0.611 12.76 30.5 65.714 
463         
 50 1037 662 0.638 13.24 30.5 73.275 
555         
 50 1042 693 0.665 13.86 30.5 80.518
Positive Control Mitomycin-C 
 0.0015    
 50 1045 565 0.541 11.30 26.5 46.753
Mitomycin-C 
 0.01      
 10 210 299 1.424 29.90 26.5 286.463
Trend: 8.816        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/29/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 392 0.375 7.84 25.5 0.000
Test Chemical Chlorpropamide 
88.5       
 50 1047 377 0.360 7.54 25.5 -4.010 
266         
 50 1051 380 0.362 7.60 25.5 -3.615 
885         
 50 1039 407 0.392 8.14 25.5 4.426
Positive Control Cyclophosphamide 
 0.5       
 50 1047 351 0.335 7.02 25.5 -10.630
Cyclophosphamide 
2.5       
 10 209 402 1.923 40.20 25.5 412.755
Trend: 0.618        
Probability: 0.268