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Study Information
Study Attribute Value
CEBS Accession Number: 002-01881-0001-0000-1
Chemical Name: Choline chloride
CASRN: 67-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 794173_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/16/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 25 526 145 0.276 5.80 26.0 0.000
Test Chemical Choline chloride 
 0.05      
 50 1051 315 0.300 6.30 26.0 8.724 
 0.5       
 50 1111 362 0.326 7.24 26.0 18.199 
5         
 50 1067 362 0.339 7.24 26.0 23.073 
50         
 50 1046 339 0.324 6.78 26.0 17.567 
500         
 50 1032 396 0.384 7.92 26.0 39.198 
5000         
 50 1067 323 0.303 6.46 26.0 9.814
Positive Control Triethylenemelamine 
 0.015     
 50 1029 2023 1.966 40.46 26.0 613.179
Trend: 2.008        
Probability: 0.022        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/16/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1051 354 0.337 7.08 26.0 0.000
Test Chemical Choline chloride 
 0.05      
 50 1058 441 0.417 8.82 26.0 23.752 
 0.5       
 50 1048 414 0.395 8.28 26.0 17.284 
5         
 50 1062 474 0.446 9.48 26.0 32.511 
50         
 50 1056 404 0.383 8.08 26.0 13.584 
500         
 50 1048 390 0.372 7.80 26.0 10.485 
5000         
 50 1040 391 0.376 7.82 26.0 11.620
Positive Control Cyclophosphamide 
1.5       
 49 1015 2373 2.338 48.43 26.0 594.115
Trend: 0.155        
Probability: 0.439