Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01881-0002-0000-2 |
Chemical Name: | Choline chloride |
CASRN: | 67-48-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 794173_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Choline chloride | 1000 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 |
2000 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
4000 | 100 | 7 | 0.070 | 7.0 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | ||
5000 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Triethylenemelamine | 0.5 | 100 | 37 | 0.370 | 32.0 | 5 | 0.050 | 4.0 | 32 | 0.320 | 26.0 | 0 | 0.000 | 0.0 |
Trend: | 1.591 | 1.600 | 0.451 | ||||||||||||
Probability: | 0.056 | 0.055 | 0.326 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 |
Test Chemical: | Choline chloride | 0.05 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
0.5 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
50 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 25 | 100 | 67 | 0.670 | 37.0 | 34 | 0.340 | 27.0 | 30 | 0.300 | 18.0 | 3 | 0.030 | 3.0 |
Cyclophosphamide | 50 | 100 | 96 | 0.960 | 49.0 | 34 | 0.340 | 29.0 | 58 | 0.580 | 30.0 | 4 | 0.040 | 4.0 | |
Trend: | 0.356 | -0.224 | 2.124 | ||||||||||||
Probability: | 0.361 | 0.589 | 0.017 |