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Study Information
Study Attribute Value
CEBS Accession Number: 002-01881-0003-0000-3
Chemical Name: Choline chloride
CASRN: 67-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 796173_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 08/20/1980    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1046 353 0.337 7.06 26.0 0.000
Test Chemical Choline chloride 
 0.005     
 50 1045 337 0.322 6.74 26.0 -4.441 
 0.05      
 50 1046 328 0.314 6.56 26.0 -7.082 
 0.5       
 50 1047 388 0.371 7.76 26.0 9.810 
50         
 50 1047 415 0.396 8.30 26.0 17.451 
500         
 50 1044 434 0.416 8.68 26.0 23.182
Positive Control Triethylenemelamine 
 0.025     
 50 1046 1654 1.581 33.08 26.0 368.555
Trend: 4.397        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/20/1980    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 361 0.344 7.22 26.0 0.000
Test Chemical Choline chloride 
 0.005     
 50 1047 385 0.368 7.70 26.0 6.750 
 0.05      
 50 1047 382 0.365 7.64 26.0 5.918 
 0.5       
 50 1046 410 0.392 8.20 26.0 13.791 
50         
 50 1047 408 0.390 8.16 26.0 13.127 
500         
 50 1048 431 0.411 8.62 26.0 19.391
Positive Control Cyclophosphamide 
1.5       
 50 1046 1851 1.770 37.02 26.0 413.723
Trend: 2.634        
Probability: 0.004