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Study Information
Study Attribute Value
CEBS Accession Number: 002-01881-0005-0000-5
Chemical Name: Choline chloride
CASRN: 67-48-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 870461_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/18/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 368 0.352 7.36 26.0 0.000
Water 
0         
 0 0 0 0.000 0.00 0.0 N/A
Test Chemical Choline chloride 
16         
 50 1051 402 0.382 8.04 26.0 0.000 
160         
 50 1034 357 0.345 7.14 26.0 0.000 
500         
 50 1032 381 0.369 7.62 26.0 0.000 
1600         
 50 1040 366 0.352 7.32 26.0 0.000 
5000         
 50 1042 404 0.388 8.08 26.0 0.000
Positive Control Mitomycin-C 
 0.005     
 50 1044 1572 1.506 31.44 26.0 0.000
Trend: 0.017        
Probability: 0.493        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/18/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 0 0 0 0.000 0.00 0.0 N/A
Negative (Not Specified) 
0         
 50 1050 458 0.436 9.16 26.0 0.000
Test Chemical Choline chloride 
16         
 50 1036 461 0.445 9.22 26.0 0.000 
50         
 50 1042 429 0.412 8.58 26.0 0.000 
160         
 50 1038 447 0.431 8.94 26.0 0.000 
500         
 50 1046 468 0.447 9.36 26.0 0.000 
1600         
 50 1038 427 0.411 8.54 26.0 0.000 
5000         
 50 1035 466 0.450 9.32 26.0 0.000
Positive Control Cyclophosphamide 
1.5       
 50 1040 2076 1.996 41.52 26.0 0.000
Trend: 0.247        
Probability: 0.403