Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01881-0006-0000-6 |
Chemical Name: | Choline chloride |
CASRN: | 67-48-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 870461_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Choline chloride | 2000 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
3000 | 100 | 5 | 0.050 | 5.0 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
4000 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 3 | 0.030 | 2.0 | 2 | 0.020 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 100 | 26 | 0.260 | 22.0 | 7 | 0.070 | 7.0 | 15 | 0.150 | 14.0 | 4 | 0.040 | 4.0 |
Trend: | 1.458 | 1.308 | 0.699 | ||||||||||||
Probability: | 0.072 | 0.095 | 0.242 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 1.0 | 0 | 0.000 | 0.0 |
Water | 0 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Choline chloride | 3000 | 100 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
4000 | 100 | 5 | 0.050 | 5.0 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 25 | 100 | 36 | 0.360 | 31.0 | 23 | 0.230 | 23.0 | 7 | 0.070 | 7.0 | 6 | 0.060 | 6.0 |
Trend: | -1.438 | -0.440 | -1.629 | ||||||||||||
Probability: | 0.925 | 0.670 | 0.948 |