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Study Information
Study Attribute Value
CEBS Accession Number: 002-01883-0001-0000-3
Chemical Name: Chromium carbonyl
CASRN: 13007-92-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 593284_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/07/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1028 538 0.523 10.76 26.0 0.000
Negative (Not Specified) 
0         
 50 1026 522 0.509 10.44 26.0 -2.785
Test Chemical Chromium carbonyl 
12.8       
 50 1024 652 0.637 13.04 34.5 21.663 
42.8       
 50 1009 567 0.562 11.34 34.5 7.375 
128         
 50 1015 654 0.644 13.08 34.5 23.118
Positive Control Mitomycin-C 
 0.001     
 50 1033 614 0.594 12.28 26.0 13.574
Mitomycin-C 
 0.01      
 5 103 156 1.515 31.20 26.0 189.400
Trend: 2.644        
Probability: 0.004        

Trial #: 2    Activation: No Activation    Date: 03/05/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1011 411 0.407 8.22 26.0 -13.517
Acetone 
0         
 50 1019 479 0.470 9.58 26.0 0.000
Test Chemical Chromium carbonyl 
70         
 50 1010 586 0.580 11.72 26.0 23.428 
100         
 50 1006 561 0.558 11.22 34.0 18.632 
128         
 50 1005 624 0.621 12.48 34.0 32.086
Positive Control Mitomycin-C 
 0.001     
 50 1015 536 0.528 10.72 26.0 12.341
Mitomycin-C 
 0.01      
 5 105 198 1.886 39.60 26.0 301.157
Trend: 4.024        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/07/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1027 530 0.516 10.60 26.0 0.000
Negative (Not Specified) 
0         
 50 1027 483 0.470 9.66 26.0 -8.868
Test Chemical Chromium carbonyl 
12.8       
 50 1029 782 0.760 15.64 26.0 47.260 
42.8       
 50 1022 676 0.661 13.52 26.0 28.171 
128         
 50 1009 785 0.778 15.70 34.5 50.755
Positive Control Cyclophosphamide 
 0.4       
 50 1028 672 0.654 13.44 26.0 26.669
Cyclophosphamide 
2         
 5 102 164 1.608 32.80 26.0 211.558
Trend: 5.912        
Probability: 0.000